MAB2617
抗Kindlin-2抗体，克隆3A3
clone 3A3, from mouse
别名:
Mitogen-inducible gene 2 protein, Pleckstrin homology domain-containing family C member 1, fermitin family homolog 2, kindlin 2, mitogen inducible gene 2 protein
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
3A3, monoclonal
Application:
ICC, WB
Citations:
35
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
3A3, monoclonal
species reactivity
human
species reactivity (predicted by homology)
bovine (based on 100% sequence homology), rat (98% sequence homology), mouse (98% sequence homology)
technique(s)
immunocytochemistry: suitable, western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... FERMT2(10979)
General description
Kindlin家族是一组黏着斑蛋白，由于它们具有结合和激活整联蛋白的能力而成为人们关注的焦点。这种能力的异常已将Kindlin与几种遗传和获得性疾病联系起来，例如Kindler综合征，癌症和白细胞粘附缺乏症。亚型Kindlin-2专门参与将migfilin蛋白募集到局部粘连位点以进行细胞ECM各种相互作用，协调肌动蛋白的生产和细胞形状的修饰。它还积极参与连接ECM粘连位点和肌动蛋白细胞骨架（Shi，2007）。Kindlin-2在整个组织中普遍表达。
~70 kDa
Immunogen
GST 标记的重组蛋白对应于人Kindlin-2。
表位：未知
Application
研究子类别
细胞骨架
细胞骨架
研究类别
细胞结构
细胞结构
该抗Kindlin-2抗体克隆3A3经过验证可用在 WB，IC 中检测Kindlin-2。
Biochem/physiol Actions
该抗体识别Kindlin-2。
Physical form
在含0.1 M Tris-甘氨酸（pH 7.4，150 mM NaCl）和0.05％叠氮化钠的缓冲液中的纯化的小鼠单克隆IgG1κ。
形式：纯化
纯化的蛋白G
Preparation Note
自收到之日起，在 2-8°C 条件下可稳定保存1年
Analysis Note
对照
HeLa细胞裂解物
HeLa细胞裂解物
通过蛋白质印迹在HeLa 细胞裂解物中进行了评估。
蛋白质印迹分析：0.5 µg/ml该抗体可在10 µg HeLa细胞裂解物中检测到Kindlin-2。
蛋白质印迹分析：0.5 µg/ml该抗体可在10 µg HeLa细胞裂解物中检测到Kindlin-2。
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Lihua Qi et al.
FEBS letters, 589(16), 2155-2162 (2015-07-06)
Kindlin-2, as an integrin-interacting protein, was known to be required for the maintenance of cardiac structure and function in zebrafish. However, the mechanism remains unclear. We found that Kindlin-2 interacts and colocalizes with α-actinin-2 at the Z-disc of mouse cardiac
Jie Lin et al.
Journal of experimental & clinical cancer research : CR, 36(1), 134-134 (2017-10-04)
Kindlin-2 is a member of the focal adhesion protein family that regulates invasion and metastasis in multiple malignancies; however, little is known about the role of Kindlin-2 in hepatocellular carcinoma (HCC) progression. Immunohistochemistry was used to investigate Kindlin-2 expression in
Huanqing Gao et al.
JCI insight, 4(13) (2019-07-12)
Kindlin-2 regulates integrin-mediated cell adhesion to and migration on the extracellular matrix. Our recent studies demonstrate important roles of kindlin-2 in regulation of mesenchymal stem cell differentiation and skeletal development. In this study, we generated adipose tissue-specific conditional knockout of
Lihua Qi et al.
Cell death & disease, 10(12), 890-890 (2019-11-27)
Kindlin-2 plays an important role in the regulation of cardiac structure and function. Depletion of Kindlin-2 contributes to cardiac hypertrophy and progressive heart failure, however, the precise mechanisms involved in this process remain unclear. GATA4 is a critical transcription factor
Khalid Sossey-Alaoui et al.
Cancer research, 77(18), 5129-5141 (2017-07-09)
Interplay between tumor cells and host cells in the tumor microenvironment dictates the development of all cancers. In breast cancer, malignant cells educate host macrophages to adopt a protumorigenic phenotype. In this study, we show how the integrin-regulatory protein kindlin-2
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