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Merck
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所有图片(4)

主要文件

MAB2617

Sigma-Aldrich

抗Kindlin-2抗体,克隆3A3

clone 3A3, from mouse

别名:

Mitogen-inducible gene 2 protein, Pleckstrin homology domain-containing family C member 1, fermitin family homolog 2, kindlin 2, mitogen inducible gene 2 protein

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About This Item

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

mouse

质量水平

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

3A3, monoclonal

种属反应性

human

种属反应性(根据同源性预测)

bovine (based on 100% sequence homology), rat (98% sequence homology), mouse (98% sequence homology)

技术

immunocytochemistry: suitable
western blot: suitable

同位素/亚型

IgG1κ

NCBI登记号

UniProt登记号

运输

wet ice

靶向翻译后修饰

unmodified

基因信息

human ... FERMT2(10979)

一般描述

Kindlin家族是一组黏着斑蛋白,由于它们具有结合和激活整联蛋白的能力而成为人们关注的焦点。这种能力的异常已将Kindlin与几种遗传和获得性疾病联系起来,例如Kindler综合征,癌症和白细胞粘附缺乏症。亚型Kindlin-2专门参与将migfilin蛋白募集到局部粘连位点以进行细胞ECM各种相互作用,协调肌动蛋白的生产和细胞形状的修饰。它还积极参与连接ECM粘连位点和肌动蛋白细胞骨架(Shi,2007)。Kindlin-2在整个组织中普遍表达。

特异性

该抗体识别Kindlin-2。

免疫原

GST 标记的重组蛋白对应于人Kindlin-2。
表位:未知

应用

研究子类别
细胞骨架
研究类别
细胞结构
该抗Kindlin-2抗体克隆3A3经过验证可用在 WB,IC 中检测Kindlin-2。

质量

通过蛋白质印迹在HeLa 细胞裂解物中进行了评估。

蛋白质印迹分析:0.5 µg/ml该抗体可在10 µg HeLa细胞裂解物中检测到Kindlin-2。

目标描述

~70 kDa

外形

在含0.1 M Tris-甘氨酸(pH 7.4,150 mM NaCl)和0.05%叠氮化钠的缓冲液中的纯化的小鼠单克隆IgG1κ。
形式:纯化
纯化的蛋白G

储存及稳定性

自收到之日起,在 2-8°C 条件下可稳定保存1年

分析说明

对照
HeLa细胞裂解物

其他说明

浓度:请参考批次特异性浓缩物的分析证书。

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


分析证书(COA)

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访问文档库

Khalid Sossey-Alaoui et al.
Cancer research, 77(18), 5129-5141 (2017-07-09)
Interplay between tumor cells and host cells in the tumor microenvironment dictates the development of all cancers. In breast cancer, malignant cells educate host macrophages to adopt a protumorigenic phenotype. In this study, we show how the integrin-regulatory protein kindlin-2
Lihua Qi et al.
FEBS letters, 589(16), 2155-2162 (2015-07-06)
Kindlin-2, as an integrin-interacting protein, was known to be required for the maintenance of cardiac structure and function in zebrafish. However, the mechanism remains unclear. We found that Kindlin-2 interacts and colocalizes with α-actinin-2 at the Z-disc of mouse cardiac
Mei Yang et al.
Reproductive sciences (Thousand Oaks, Calif.), 21(6), 696-703 (2013-12-18)
Hyperandrogenemia is the leading defect in patients with polycystic ovary syndrome (PCOS) and considered to be involved in the ovulation dysfunction of PCOS. During the process of ovulation, granulosa cells (GCs) undergo epithelial-mesenchymal transition (EMT), and integrin-interacting protein kindlin 2
Jie Lin et al.
Journal of experimental & clinical cancer research : CR, 36(1), 134-134 (2017-10-04)
Kindlin-2 is a member of the focal adhesion protein family that regulates invasion and metastasis in multiple malignancies; however, little is known about the role of Kindlin-2 in hepatocellular carcinoma (HCC) progression. Immunohistochemistry was used to investigate Kindlin-2 expression in
Huanqing Gao et al.
JCI insight, 4(13) (2019-07-12)
Kindlin-2 regulates integrin-mediated cell adhesion to and migration on the extracellular matrix. Our recent studies demonstrate important roles of kindlin-2 in regulation of mesenchymal stem cell differentiation and skeletal development. In this study, we generated adipose tissue-specific conditional knockout of

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