推荐产品
生物来源
mouse
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
3A3, monoclonal
种属反应性
human
种属反应性(根据同源性预测)
bovine (based on 100% sequence homology), rat (98% sequence homology), mouse (98% sequence homology)
技术
immunocytochemistry: suitable
western blot: suitable
同位素/亚型
IgG1κ
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... FERMT2(10979)
一般描述
Kindlin家族是一组黏着斑蛋白,由于它们具有结合和激活整联蛋白的能力而成为人们关注的焦点。这种能力的异常已将Kindlin与几种遗传和获得性疾病联系起来,例如Kindler综合征,癌症和白细胞粘附缺乏症。亚型Kindlin-2专门参与将migfilin蛋白募集到局部粘连位点以进行细胞ECM各种相互作用,协调肌动蛋白的生产和细胞形状的修饰。它还积极参与连接ECM粘连位点和肌动蛋白细胞骨架(Shi,2007)。Kindlin-2在整个组织中普遍表达。
特异性
该抗体识别Kindlin-2。
免疫原
GST 标记的重组蛋白对应于人Kindlin-2。
表位:未知
应用
研究子类别
细胞骨架
细胞骨架
研究类别
细胞结构
细胞结构
该抗Kindlin-2抗体克隆3A3经过验证可用在 WB,IC 中检测Kindlin-2。
质量
通过蛋白质印迹在HeLa 细胞裂解物中进行了评估。
蛋白质印迹分析:0.5 µg/ml该抗体可在10 µg HeLa细胞裂解物中检测到Kindlin-2。
蛋白质印迹分析:0.5 µg/ml该抗体可在10 µg HeLa细胞裂解物中检测到Kindlin-2。
目标描述
~70 kDa
外形
在含0.1 M Tris-甘氨酸(pH 7.4,150 mM NaCl)和0.05%叠氮化钠的缓冲液中的纯化的小鼠单克隆IgG1κ。
形式:纯化
纯化的蛋白G
储存及稳定性
自收到之日起,在 2-8°C 条件下可稳定保存1年
分析说明
对照
HeLa细胞裂解物
HeLa细胞裂解物
其他说明
浓度:请参考批次特异性浓缩物的分析证书。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
未找到合适的产品?
试试我们的产品选型工具.
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Cancer research, 77(18), 5129-5141 (2017-07-09)
Interplay between tumor cells and host cells in the tumor microenvironment dictates the development of all cancers. In breast cancer, malignant cells educate host macrophages to adopt a protumorigenic phenotype. In this study, we show how the integrin-regulatory protein kindlin-2
FEBS letters, 589(16), 2155-2162 (2015-07-06)
Kindlin-2, as an integrin-interacting protein, was known to be required for the maintenance of cardiac structure and function in zebrafish. However, the mechanism remains unclear. We found that Kindlin-2 interacts and colocalizes with α-actinin-2 at the Z-disc of mouse cardiac
Reproductive sciences (Thousand Oaks, Calif.), 21(6), 696-703 (2013-12-18)
Hyperandrogenemia is the leading defect in patients with polycystic ovary syndrome (PCOS) and considered to be involved in the ovulation dysfunction of PCOS. During the process of ovulation, granulosa cells (GCs) undergo epithelial-mesenchymal transition (EMT), and integrin-interacting protein kindlin 2
Journal of experimental & clinical cancer research : CR, 36(1), 134-134 (2017-10-04)
Kindlin-2 is a member of the focal adhesion protein family that regulates invasion and metastasis in multiple malignancies; however, little is known about the role of Kindlin-2 in hepatocellular carcinoma (HCC) progression. Immunohistochemistry was used to investigate Kindlin-2 expression in
JCI insight, 4(13) (2019-07-12)
Kindlin-2 regulates integrin-mediated cell adhesion to and migration on the extracellular matrix. Our recent studies demonstrate important roles of kindlin-2 in regulation of mesenchymal stem cell differentiation and skeletal development. In this study, we generated adipose tissue-specific conditional knockout of
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门