生物来源
mouse
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
21C8, monoclonal
种属反应性
human
制造商/商品名称
Chemicon®
技术
flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
同位素/亚型
IgG1
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... ITGB1(3688)
相关类别
特异性
Reacts with the human integrin beta1 subunit. Specificity verified by preclearing of beta1in immunoprecipitation, flow cytometry on transfectant cells displaying human beta1 integrin, and reactivity with purified beta1.
免疫原
Jurkat T-leukemic cell line
应用
Anti-Integrin β1 Antibody, clone 21C8 is an antibody against Integrin β1 for use in FC, IP, FUNC, IH.
Immunoprecipitation
Immunohistochemistry on frozen sections
Flow cytometry
Stimulates adhesion of cells to extracellular matrix proteins (Wilkins et al., 1996)
Does not bind reduced beta1 integrin on Western blot
Optimal working dilutions must be determined by end user.
Immunohistochemistry on frozen sections
Flow cytometry
Stimulates adhesion of cells to extracellular matrix proteins (Wilkins et al., 1996)
Does not bind reduced beta1 integrin on Western blot
Optimal working dilutions must be determined by end user.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Integrins
Integrins
外形
Format: Purified
Purified immunoglobulin from Protein A Sepharose™ chromatography. Liquid in 0.02M PB pH 7.6, 0.25M NaCl containing 0.1% sodium azide.
储存及稳定性
Maintain at 2-8°C in undiluted aliquots for up to 6 months.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Sepharose is a trademark of Cytiva
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Stretch of beta 1 integrin activates an outwardly rectifying chloride current via FAK and Src in rabbit ventricular myocytes.
Browe, DM; Baumgarten, CM
The Journal of General Physiology null
David M Browe et al.
The Journal of general physiology, 127(3), 237-251 (2006-03-01)
Stretch of beta1 integrins activates an outwardly rectifying, tamoxifen-sensitive Cl(-) current (Cl(-) SAC) via AT1 receptors, NADPH oxidase, and reactive oxygen species, and Cl(-) SAC resembles the volume-sensitive Cl(-) current (I(Cl,swell)). Epidermal growth factor receptor (EGFR) kinase undergoes transactivation upon
Rebecca J Burkhalter et al.
The Journal of biological chemistry, 290(36), 22143-22154 (2015-07-16)
During tumor progression, epithelial ovarian cancer (EOC) cells undergo epithelial-to-mesenchymal transition (EMT), which influences metastatic success. Mutation-dependent activation of Wnt/β-catenin signaling has been implicated in gain of mesenchymal phenotype and loss of differentiation in several solid tumors; however, similar mutations
hGAAP promotes cell adhesion and migration via the stimulation of store-operated Ca2+ entry and calpain 2.
Saraiva, N; Prole, DL; Carrara, G; Johnson, BF; Taylor, CW; Parsons, M; Smith, GL
The Journal of cell biology null
R C Casey et al.
The American journal of pathology, 159(6), 2071-2080 (2001-12-06)
Ovarian carcinoma multicellular spheroids are an in vitro model of micrometastasis whose adhesive abilities have not been elucidated. In this study, we identified adhesion molecules that mediate the formation of ovarian carcinoma spheroids and their subsequent adhesion to extracellular matrix
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