MAB2247
抗-整合素β 1抗体，克隆12G10
clone 12G10, Chemicon®, from mouse
别名:
Integrin beta-1, CD29, Glycoprotein Iia, GPIIA, Integrin VLA-4 subunit beta, Very late activation protein, beta polypeptide
产品名称
抗-整合素β 1抗体，克隆12G10, clone 12G10, Chemicon®, from mouse
biological source
mouse
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
12G10, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
cell culture | mammalian: suitable
flow cytometry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ITGB1(3688)
Analysis Note
对照
扁桃体，人皮肤组织
扁桃体，人皮肤组织
Application
已发表抗整联蛋白β1抗体，克隆12G10可检测整联蛋白β1 & 水平，&经验证可用于ELISA、FC、IP、FUNC、CULT &WB。
流式细胞术： 1:25-1:50
ELISA ：10 μg/mL
蛋白质印迹：已知仅在非还原条件下与人β1整联蛋白亚基反应{Mould，1995}。
刺激α5β1与纤维连接蛋白的相互作用{Mould，1995}。
最佳工作稀释度必须由最终用户进行确定。
ELISA ：10 μg/mL
蛋白质印迹：已知仅在非还原条件下与人β1整联蛋白亚基反应{Mould，1995}。
刺激α5β1与纤维连接蛋白的相互作用{Mould，1995}。
最佳工作稀释度必须由最终用户进行确定。
研究子类别
整联蛋白
整联蛋白
研究类别
细胞结构
细胞结构
Biochem/physiol Actions
MAB2247识别人β1整联蛋白。 已证明该抗体可识别配体诱导的结合位点，在存在纤维连接蛋白配体的情况下，抗体结合增加。 该抗体还增强α5-β1纤维连接蛋白的各种相互作用。 MAB2247不与小鼠或大鼠样品发生交叉反应。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
88kda
整联蛋白β-1（UniProt P05556；也被称为CD29、糖蛋白Iia、GPIIA、整联蛋白VLA-4亚基β、极晚激活蛋白、β多肽）在人体中由ITGB1（也被称为FNRB、MDF2、MSK12、VLA-BETA、VLAB）基因（基因ID 3688）进行编码。整联蛋白β-1是一种130 kDa的跨膜糖蛋白，可与多种整联蛋白α亚基（包括α1、α2、α3、α4、α5和α6）相互作用，形成与特定细胞外基质蛋白结合的功能性受体复合物。整联蛋白受体可调节多种重要的生物学功能，包括胚胎发育、伤口修复、止血和防止程序性细胞死亡。它们还涉及异常的病理状态，例如肿瘤定向的血管生成、肿瘤生长和转移。这些异二聚体受体将细胞质肌动蛋白细胞骨架与细胞外基质和/或相邻细胞中存在的蛋白质进行桥接。整联蛋白与细胞外基质之间的相互作用会导致信号转导途径的激活和基因表达的调节。
Immunogen
从HT1080纤维肉瘤细胞提取物中纯化的人β1整联蛋白制剂。
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
形式：纯化
纯化的免疫球蛋白。 磷酸盐缓冲盐水液体，含0.1%叠氮化钠。
纯化的蛋白 A
Preparation Note
以未稀释的等分试样可在2–8°C冷藏保存长达1个月。对于长期储存，在-20°C下保持长达12个月。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
未找到合适的产品？
试试我们的产品选型工具.
存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Zhenwei Lu et al.
eLife, 5 (2016-12-09)
Integrins are transmembrane receptors composed of α and β subunits. Although most integrins contain β1, canonical activation mechanisms are based on studies of the platelet integrin, αIIbβ3. Its inactive conformation is characterized by the association of the αIIb transmembrane and
Magdalene Michael et al.
The Journal of investigative dermatology, 134(3), 773-782 (2013-09-13)
Bullous pemphigoid antigen 1 (BPAG1-e, also known as BP230) is a member of the plakin family of hemidesmosome cytoskeletal linker proteins that is encoded by an isoform of the dystonin (DST) gene. Recently, we reported two unrelated families with homozygous
Dhaarmini Rajshankar et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 26(11), 4429-4444 (2012-07-26)
IL-1β is a prominent proinflammatory cytokine that mediates degradation of extracellular matrix proteins through increased expression of matrix metalloproteinases, which involves a signaling pathway in adherent cells that is restricted by focal adhesions. Currently, the mechanism by which IL-1β affects
Catherine T Choy et al.
Endocrine-related cancer, 21(1), 85-99 (2013-11-06)
Anosmin-1, encoded by the KAL1 gene, is an extracellular matrix (ECM)-associated protein which plays essential roles in the establishment of olfactory and GNRH neurons during early brain development. Loss-of-function mutations of KAL1 results in Kallmann syndrome with delayed puberty and
Md Saimon Mia et al.
European journal of cell biology, 102(2), 151316-151316 (2023-04-22)
The expression of the angiotensin-converting enzyme 2 (ACE2) is altered in multiple chronic kidney diseases like hypertension and renal fibrosis, where the signaling from the basal membrane proteins is critical for the development and progression of the various pathologies. Integrins
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持