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Dear Customer:

The current international situation is complex and volatile, and uncertain tariff policies may potentially impact our product prices. Given these uncertainties, we value your understanding regarding order-related matters.

If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

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Merck
CN
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主要文件

MAB1965

Sigma-Aldrich

Anti-Integrin beta 1 (CD29) Antibody

CHEMICON®, mouse monoclonal, JB1A (J10)

别名:

CD29

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100 μL
CN¥6,364.93

CN¥6,364.93

预计发货时间April 29, 2025详情

针对您的靶标提供了无防腐剂重组抗体。欢迎选购 ZRB1230
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选择尺寸

变更视图
100 μL
CN¥6,364.93

About This Item

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

CN¥6,364.93

预计发货时间April 29, 2025详情

针对您的靶标提供了无防腐剂重组抗体。欢迎选购 ZRB1230
登录查看协议价
获取大包装报价

产品名称

抗整合素β1抗体，氨基酸82-87，克隆JB1A （又称J10）, ascites fluid, clone JB1A (J10), Chemicon®

生物来源

mouse

质量水平

100
300

抗体形式

ascites fluid

抗体产品类型

primary antibodies

克隆

JB1A (J10), monoclonal

种属反应性

human

制造商/商品名称

Chemicon®

技术

flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

同位素/亚型

IgG1

相关类别

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此商品
MAB1987AB1952MAB2000
Anti-Integrin β1 Antibody, a.a. 82-87, clone JB1A (a.k.a. J10) ascites fluid, clone JB1A (J10), Chemicon®

MAB1965

Anti-Integrin β1 Antibody, a.a. 82-87, clone JB1A (a.k.a. J10)

Anti-Integrin β1 Antibody, clone P4C10 culture supernatant, clone P4C10, Chemicon®

MAB1987

Anti-Integrin β1 Antibody, clone P4C10

Anti-Integrin beta1 Antibody, Cytosolic serum, Chemicon®

AB1952

Anti-Integrin beta1 Antibody, Cytosolic

Anti-Integrin β1 Antibody, clone HB1.1 clone HB1.1, Chemicon®, from mouse

MAB2000

Anti-Integrin β1 Antibody, clone HB1.1

clone

JB1A (J10), monoclonal

clone

P4C10, monoclonal

clone

polyclonal

clone

HB1.1, monoclonal

antibody form

ascites fluid

antibody form

culture supernatant

antibody form

serum

antibody form

purified immunoglobulin

biological source

mouse

biological source

mouse

biological source

rabbit

biological source

mouse

technique(s)

flow cytometry: suitable, immunoprecipitation (IP): suitable, immunohistochemistry: suitable, western blot: suitable

technique(s)

ELISA: suitable, immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable

technique(s)

immunoprecipitation (IP): suitable, western blot: suitable

technique(s)

flow cytometry: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

wet ice

一般描述

整合素家族的主要功能是介导细胞-细胞和细胞-基质的粘附相互作用。CD29普遍存在，组织分布广泛，但在红细胞上不表达，仅在粒细胞上弱表达。整合素在细胞粘附和迁移中发挥重要作用，其正常功能在诱导和维持细胞分化中起着至关重要的作用。CD29的缺失或下调被认为是癌细胞获得更具侵袭性和分化表型的一般途径之一。此外，免疫组织化学发现，在低分化的结直肠癌和乳腺癌中，整合素的缺失或下调相对频繁。

特异性

与人整合素β1反应。注：整合素β 1在除红细胞外的所有组织/细胞类型中表达。JB1a识别的表位最近被定位到成熟的β 1整合素链的82-87残基上。在这项研究中，发现Mn++抑制JB1a结合成熟β 1整合素、对应于残基82-87的合成肽{Ni, 1998}。

免疫原

纯化β 1整合素和Jurkat细胞
表位：氨基酸82-87

应用

Jurkat与胶原和纤维连接蛋白结合的抑制作用：
1:100 注：表位对胰蛋白酶敏感；用PBS + EDTA（2mM）或其他非酶法制备细胞。JB1A胰蛋白酶化细胞不会发生阻滞。

免疫沉淀：1:250-500

蛋白质印迹（还原，115 kDa；非还原性，130 kDa）；1:1000-2000

注：当镁离子浓度超过0.5mM时，抗体的结合可能被抑制。

免疫细胞化学/免疫组织化学。 JB1A可用于流式细胞术和培养基中未固定的细胞{Akimov, 2001; Blood 98(5):1567-1576}。通常情况下，在一抗孵育后用2-3% PFA固定 5 分钟有助于获得强信号，因为它能将一级抗体固定在组织上。

FACS：JB1A主要用于活细胞，抗体浓度为1:200-1:500，然后使用山羊抗小鼠共轭继代。

最佳工作稀释度必须由最终用户进行确定。
研究子类别
整合素
研究类别
细胞结构
该抗整合素β1抗体，氨基酸82-87，克隆JB1A （又称J10）经验证可用于FC、IH、IP、FUNC、WB中整合素β1的检测。

目标描述

88kda

外形

不含防腐剂的腹水。
未纯化

储存及稳定性

自收到之日起在-20°C可稳定保存2年。避免反复冻融。 为了最大程度地回收产品，在融化后和取下盖子之前，将原始小瓶进行离心。

分析说明

对照
人肺、肝和骨骼肌组织

其他说明

浓度：请参考批次特异性浓缩物的检验报告。

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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