推荐产品
生物来源
mouse
抗体形式
ascites fluid
抗体产品类型
primary antibodies
克隆
3E1, monoclonal
种属反应性
human
制造商/商品名称
Chemicon®
技术
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
靶向翻译后修饰
unmodified
基因信息
human ... ITGB4(3691)
一般描述
整联蛋白β4是一种糖蛋白，可与a6整联蛋白结合形成a6/B4复合物。整联蛋白α6/β4是层粘连蛋白的受体。它在上皮细胞的半桥粒中起关键的结构作用。整联蛋白β4基因缺陷是导致致死性大疱性表皮松解伴幽门闭锁（EB PA）的原因；又称交界性大疱性表皮松解伴幽门闭锁（PA-JEB）或先天性皮肤发育不全伴胃肠道闭锁。EB-PA的特征是粘膜皮肤脆弱和胃肠道闭锁，最常影响幽门。此外，整联蛋白β4基因的缺陷是泛发性萎缩性良性大疱性表皮松解（GABEB）的一个原因。这种非致命形式的交界性大疱性表皮松解的特征是皮肤终生水泡，与头发和牙齿异常有关。
特异性
与人β4整联蛋白反应。抗原存在于上皮细胞上。
应用
以大约1：200的免疫荧光染色人类皮肤；需要丙酮固定。
也适用于免疫沉淀和流式细胞术分析。
最佳工作稀释度必须由最终用户进行确定。
也适用于免疫沉淀和流式细胞术分析。
最佳工作稀释度必须由最终用户进行确定。
该抗整联蛋白4β抗体（克隆3E1）经验证可用于FC、IC、IH、IP检测整联蛋白β4。
外形
不含防腐剂的未纯化腹水。
其他说明
浓度：请参考批次特异性浓缩物的分析证书。
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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