MAB1948P

抗-硫酸乙酰肝素蛋白聚糖(Perlecan)抗体，克隆A7L6

Name: 抗-硫酸乙酰肝素蛋白聚糖(Perlecan)抗体，克隆A7L6
Brand: MM

clone A7L6, from rat

别名:

heparan sulfate proteoglycan 2, Schwartz-Jampel syndrome 1 (chondrodystrophic myotonia), endorepellin (domain V region), perlecan proteoglycan, heparan sulfate proteoglycan of basement membrane

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关于此项目

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

主要文件

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产品名称

抗-硫酸乙酰肝素蛋白聚糖(Perlecan)抗体，克隆A7L6, clone A7L6, from rat

biological source

rat

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

A7L6, monoclonal

species reactivity

human

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG2aκ

NCBI accession no.

NP_005520

UniProt accession no.

P98160

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... HSPG2(3339)

Application

硫酸乙酰肝素蛋白聚糖(Perlecan)抗体（克隆A7L6）经过IH、IC、WB & IP应用验证，用于检测硫酸乙酰肝素蛋白聚糖(Perlecan)。

免疫组化分析：一个先前批次的抗体以 1：100 的稀释度在大细胞癌组织中检测到硫酸乙酰肝素蛋白聚糖。

蛋白质免疫印迹分析(WB)：一个先前批次已被独立实验室用于WB。 (Hagen, 1993; Brown, 1999)。

免疫沉淀分析(IP)：先前批次已在一个独立实验室中进行了IP测试。 (Couchman, 1989).

研究子类别
ECM 蛋白

研究类别
细胞结构

Biochem/physiol Actions

该抗体识别硫酸乙酰肝素蛋白聚糖(perlecan)的高分子量核心蛋白。与层粘连蛋白、胶原IV、巢蛋白或纤连蛋白无交叉反应性(Horiguchi, 1989)。

Analysis Note

对照
HeLa和A431细胞

通过免疫细胞化学在HeLa和A431细胞中进行评估。

免疫细胞化学分析： 1:500稀释的该抗体在HeLa和A431细胞中检测到硫酸乙酰肝素蛋白聚糖。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的人类或动物食用或应用。

General description

硫酸乙酰肝素蛋白聚糖(HSPG)广泛分布于所有哺乳动物组织的细胞表面和胞外基质中，尤其在基底膜中心。大脑中的HSPG为肌营养不良蛋白聚糖(dystroglycan)、多配体蛋白聚糖(N-syndecan)、糖基磷脂酰肌醇锚定蛋白聚糖(glypican)和串珠蛋白聚糖(perlecan)。组成硫酸乙酰肝素蛋白聚糖的核心蛋白各有不同，被认为决定了HSPG在细胞膜（syndecan和glypican）与细胞外基质（perlecan和dystroglycan）中的定位。HSPG的潜在功能包括细胞增殖、分化、粘附、迁移和形态发生。
硫酸乙酰肝素蛋白聚糖抗体在组织中稳定地与基底膜强烈反应。克隆A7L6识别大分子硫酸乙酰肝素蛋白聚糖(perlecan)的IV区域。免疫反应性不依赖于半乳糖胺聚糖结构；因此，识别表位对肝素酶不敏感。

Immunogen

EHS小鼠肿瘤来源硫酸乙酰肝素蛋白聚糖

表位：HSPG核心蛋白

Other Notes

替代：MAB1948

浓度：请参考批次特异性浓缩物的检验报告。

Physical form

形式：纯化

纯化的大鼠单克隆IgG2aκ溶于含0.1 M Tris-甘氨酸（pH 7.4），150 mM NaCl和0.05％叠氮化钠的缓冲液中。

蛋白G纯化

Preparation Note

自收到之日起，在2-8°C条件下可稳定保存1年。

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存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Hyperglycemia induces altered expressions of angiogenesis associated molecules in the trophoblast.

Shu-Chun Chang et al.

Evidence-based complementary and alternative medicine : eCAM, 2013, 457971-457971 (2013-08-29)

We previously reported that the increased level of perlecan with altered glycosaminoglycan (GAG) substitution was present in the placenta with gestational diabetes mellitus (GDM) and in the trophoblasts cultured under hyperglycemic condition. Trophoblast is the first cell lineage to differentiate

Collagen XVIII Deposition in the Basement Membrane Zone beneath the Newly Forming Epidermis during Wound Healing in Mice.

Takahiro Maeba et al.

Acta medica Okayama, 73(2), 135-146 (2019-04-25)

The basement membrane (BM) is composed of various extracellular molecules and regulates tissue regeneration and maintenance. Here, we demonstrate that collagen XVIII was spatiotemporally expressed in the BM during skin wound healing in a mouse excisional wound-splinting model. Re-epithelialization was

Characterization and distribution of hyaluronan and the proteoglycans decorin, biglycan and perlecan in the developing embryonic mouse gonad.

C A Miqueloto et al.

Journal of anatomy, 211(1), 16-25 (2007-06-05)

The morphogenesis of tissues and organs requires dynamic changes in cells and in extracellular matrix components. It is known that various extracellular matrix molecules are of fundamental importance for gonad differentiation and growth. In the adult testis, the extracellular matrix

Focal cerebral ischemia induces active proteases that degrade microvascular matrix.

Shunichi Fukuda et al.

Stroke, 35(4), 998-1004 (2004-03-06)

Focal cerebral ischemia causes microvessel matrix degradation and generates proteases known to degrade this matrix. However, proof that the proteases generated do indeed degrade vascular matrix is lacking. Here we demonstrate that active proteases derived from ischemic tissue after middle

Diverse roles of E-cadherin in the morphogenesis of the submandibular gland: insights into the formation of acinar and ductal structures.

Janice L Walker et al.

Developmental dynamics : an official publication of the American Association of Anatomists, 237(11), 3128-3141 (2008-09-26)

The formation of acinar and ductal structures during epithelial tissue branching morphogenesis is not well understood. We report that in the mouse submandibular gland (SMG), acinar and ductal cell fates are determined early in embryonic morphogenesis with E-cadherin playing pivotal

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抗-硫酸乙酰肝素蛋白聚糖(Perlecan)抗体，克隆A7L6

clone A7L6, from rat

选择尺寸

关于此项目

主要文件

属性

产品名称

biological source

conjugate

antibody form

antibody product type

clone

species reactivity

technique(s)

isotype

NCBI accession no.

UniProt accession no.

shipped in

target post-translational modification

Quality Level

Gene Information

相关类别

说明

Application

Biochem/physiol Actions

Analysis Note

Disclaimer

General description

Immunogen

Other Notes

Physical form

Preparation Note

安全信息

存储类别

wgk

flash_point_f

flash_point_c

文件

分析证书(COA)

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