生物来源
mouse
质量水平
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
1808, monoclonal
种属反应性
chicken, mouse, rat, human
制造商/商品名称
Chemicon®
技术
immunohistochemistry: suitable
western blot: suitable
同位素/亚型
IgG1
NCBI登记号
UniProt登记号
运输
dry ice
靶向翻译后修饰
unmodified
基因信息
human ... DMD(1756)
特异性
通过蛋白质印迹，MAB1645可识别相对分子量为300 kD的单一蛋白。可与哺乳动物骨骼肌肌营养不良蛋白反应。无法对mdx小鼠肌肉进行染色。可标记正常人体肌肉，但无法标记杜氏肌肉。
染色模式：
在正常小鼠膈肌冷冻切片上，MAB1645可对整个肌膜进行强免疫荧光染色，对神经肌肉接头的染色尤为强烈。
种属反应性：
可标记大鼠、鸡和非洲爪蟾的骨骼肌。可标记大鼠和正常（但不是mdx）小鼠的心肌。还可标记鸡胗平滑肌。
染色模式：
在正常小鼠膈肌冷冻切片上，MAB1645可对整个肌膜进行强免疫荧光染色，对神经肌肉接头的染色尤为强烈。
种属反应性：
可标记大鼠、鸡和非洲爪蟾的骨骼肌。可标记大鼠和正常（但不是mdx）小鼠的心肌。还可标记鸡胗平滑肌。
免疫原
从电鳐属突触后膜提取的外周膜蛋白。
应用
肌营养不良蛋白抗体（克隆1808）可检测肌营养不良蛋白水平 & 已发表 & 经验证可用于 WB、IH。
蛋白质印迹
免疫组化
最佳工作稀释度必须由最终用户确定。
免疫组化
最佳工作稀释度必须由最终用户确定。
外形
形式：纯化
液体，溶于含有0.25 mM NaCl和0.1%叠氮化钠的0.02M磷酸盐缓冲液（pH 7.6）中。
储存及稳定性
以方便的等分试样在-20ºC保持长达12个月。应避免反复冻/融循环。
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Andreas Schaefer et al.
Scientific reports, 9(1), 5710-5710 (2019-04-07)
Mechanical unloading (MU) by implantation of left ventricular assist devices (LVAD) has become clinical routine. This procedure has been shown to reverse cardiac pathological remodeling, with the underlying molecular mechanisms incompletely understood. Most studies thus far were performed in non-standardized
Andreas Schaefer et al.
PloS one, 11(2), e0148259-e0148259 (2016-02-04)
Previous small animal models for simulation of mechanical unloading are solely performed in healthy or infarcted hearts, not representing the pathophysiology of hypertrophic and dilated hearts emerging in heart failure patients. In this article, we present a new and economic
Mariana Fernandez-Caggiano et al.
Nature metabolism, 2(11), 1223-1231 (2020-10-28)
Cardiomyocytes rely on metabolic substrates, not only to fuel cardiac output, but also for growth and remodelling during stress. Here we show that mitochondrial pyruvate carrier (MPC) abundance mediates pathological cardiac hypertrophy. MPC abundance was reduced in failing hypertrophic human
Tessa R Werner et al.
Scientific reports, 9(1), 11494-11494 (2019-08-09)
Afterload enhancement (AE) of rat engineered heart tissue (EHT) in vitro leads to a multitude of changes that in vivo are referred to as pathological cardiac hypertrophy: e.g., cardiomyocyte hypertrophy, contractile dysfunction, reactivation of fetal genes and fibrotic changes. Moreover
Payam Soltanzadeh et al.
Neuromuscular disorders : NMD, 20(8), 499-504 (2010-07-16)
Manifesting carriers of DMD gene mutations may present diagnostic challenges, particularly in the absence of a family history of dystrophinopathy. We review the clinical and genetic features in 15 manifesting carriers identified among 860 subjects within the United Dystrophinopathy Project
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