MAB1567A4
Anti-MAG Antibody, clone 513, Alexa Fluor™ 488 Conjugate
clone 513, from mouse, ALEXA FLUOR™ 488
别名:
Myelin-associated glycoprotein, Siglec-4a
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
ALEXA FLUOR™ 488
Clone:
513, monoclonal
Application:
immunocytochemistry
immunohistochemistry
immunohistochemistry
Species reactivity:
rat, mouse
Citations:
3
Technique(s):
immunocytochemistry: suitable
immunohistochemistry: suitable
immunohistochemistry: suitable
Uniprot accession no.:
产品名称
Anti-MAG Antibody, clone 513, Alexa Fluor™ 488 Conjugate, clone 513, from mouse, ALEXA FLUOR™ 488
biological source
mouse
conjugate
ALEXA FLUOR™ 488
antibody form
purified antibody
antibody product type
primary antibodies
clone
513, monoclonal
species reactivity
rat, mouse
species reactivity (predicted by homology)
chicken (based on 100% sequence homology), human (based on 100% sequence homology), frog (based on 100% sequence homology), bovine (based on 100% sequence homology)
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MAG(4099)
Analysis Note
Control
Adult mouse brain tissue
Adult mouse brain tissue
Evaluated by Immunohistochemistry in adult mouse brain tissue.
Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected MAG in adult mouse brain tissue.
Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected MAG in adult mouse brain tissue.
Application
Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected MAG in rat E18 primary cortex cells.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Neuroscience
Developmental Neuroscience
This Anti-MAG Antibody, clone 513, Alexa Fluor 488 Conjugate is validated for use in IC, IH for the detection of MAG.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
69 kDa calculated
Myelin-associated glycoprotein (MAG), a member of the immunoglobulin superfamily, is a membrane glycoprotein of 100 kDa, and is thought to be involved in the process of myelination. Axonal regeneration in the adult central nervous system (CNS) is limited by two proteins in myelin, Nogo and MAG. MAG has been implicated in the inhibition of nerve regeneration in the CNS.
Immunogen
L2 epitope carrying glycoprotein extract of 1-2 day old chicken brain
Physical form
Protein A purified
Purified mouse monoclonal IgG1 conjugated to Alexa Fluor™ 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Preparation Note
Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Legal Information
ALEXA FLUOR is a trademark of Life Technologies
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Yevgeniya A Mironova et al.
eLife, 5 (2016-03-24)
Proper development of the CNS axon-glia unit requires bi-directional communication between axons and oligodendrocytes (OLs). We show that the signaling lipid phosphatidylinositol-3,5-bisphosphate [PI(3,5)P2] is required in neurons and in OLs for normal CNS myelination. In mice, mutations of Fig4, Pikfyve
Allison Y Louie et al.
Journal of neuroinflammation, 20(1), 190-190 (2023-08-19)
Recent data suggest that myelin may be altered by physiological events occurring outside of the central nervous system, which may cause changes to cognition and behavior. Similarly, peripheral infection by non-neurotropic viruses is also known to evoke changes to cognition
Lizhao Feng et al.
iScience, 26(11), 108037-108037 (2023-10-23)
Myelin defects cause a collection of myelin disorders in the brain. The lack of human models has limited us from better understanding pathological mechanisms of myelin diseases. While human induced pluripotent stem cell (hiPSC)-derived spheroids or organoids have been used
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