推荐产品
生物来源
mouse
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
6B4, monoclonal
种属反应性
human
制造商/商品名称
Chemicon®
技术
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
同位素/亚型
IgG1
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... ITGA6(3655)
一般描述
Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated alpha and beta subunits. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. In general, integrin function as receptors for extracellular matrix proteins. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. For integrin subunits alpha 3 and alpha6, two cytoplasmic variants, A and B, have been identified.
特异性
MAB1358 recognizes specifically the cytoplasmic domain of integrin subunit alpha 6B. The antibody stains the basement membrane zone of ducts and acini of salivary gland, kidney tubules, epithelium of colonic crypts and weakly stains sweat glands and sebaceous glands.
Broad species reactivity is expected due to the conserved nature of the epitope.
Broad species reactivity is expected due to the conserved nature of the epitope.
免疫原
Synthetic Peptide to the cytoplasmic domain of integrin subunit alpha6B including an appending N-terminal cysteine: CSRYDDSVPRYHAVRIRKEEREIKDEKYIDNLEKK
应用
Anti-Integrin α6B Antibody, cytoplasmic domain, clone 6B4 is an antibody against Integrin α6B for use in WB, IC, IH.
Western blotting: 1:100-1:500
Immunocytochemistry: 1:100-1:500 on frozen sections, 1:50-1:100 with avidin-biotin complex detection
Immunocytochemistry
Optimal working dilutions must be determined by the end user.
Immunocytochemistry: 1:100-1:500 on frozen sections, 1:50-1:100 with avidin-biotin complex detection
Immunocytochemistry
Optimal working dilutions must be determined by the end user.
外形
Format: Purified
储存及稳定性
Store at 2-8°C, or -20°C in small aliquots for up to 12 months after date of receipt. Avoid freeze/thaw cycles.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 2
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