推荐产品
生物来源
mouse
质量水平
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
2TMP05, monoclonal
种属反应性
human, mouse, bovine, guinea pig, rabbit, rat
制造商/商品名称
Chemicon®
技术
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI登记号
UniProt登记号
1 of 4
此商品 | GF91798543 | GF37454913 | GF15970080 |
|---|---|---|---|
| form foil | form foil | form foil | form foil |
| assay 99.99% | assay ≥99.99% | assay 99.99% | assay 99.99% |
| resistivity 12.7 μΩ-cm, 20°C | resistivity 12.7 μΩ-cm, 20°C | resistivity 12.7 μΩ-cm, 20°C | resistivity 12.7 μΩ-cm, 20°C |
| bp 2672 °C (lit.) | bp 2672 °C (lit.) | bp 2672 °C (lit.) | bp 2672 °C (lit.) |
| mp 1857 °C (lit.) | mp 1857 °C (lit.) | mp 1857 °C (lit.) | mp 1857 °C (lit.) |
特异性
MAB13446 recognizes a protein of 21kDa, identified as tissue inhibitor of metalloproteinase-2 (TIMP-2). TIMP-2 is closely related to TIMP-1 and shows the highest binding affinity to both the latent (pro) and active forms of 72kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. CHEMICON MAB13446 may be used to evaluate the invasive nature of some tumor types and determine the tissue distribution of TIMPs in other tumors such as adenomas and also its normal tissue.
CELLULAR LOCALIZATION:
Cytoplasmic
CELLULAR LOCALIZATION:
Cytoplasmic
免疫原
A synthetic peptide from the N-terminal region of human TIMP-2 protein.
应用
Detect TIMP-2 using this Anti-TIMP-2 Antibody, clone 2TMP05 validated for use in WB, IH(P).
Immunohistology (formalin/paraffin only): 2-4μg/ml 30 min at RT.
Western blotting: 1μg/ml for 2 hrs at RT.
(Staining of formalin-fixed tissues REQUIRES boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 min. followed by cooling at RT for 20 min).
The optimal dilution for a specific application under a given set of experimental conditions should be determined by the investigator.
Western blotting: 1μg/ml for 2 hrs at RT.
(Staining of formalin-fixed tissues REQUIRES boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 min. followed by cooling at RT for 20 min).
The optimal dilution for a specific application under a given set of experimental conditions should be determined by the investigator.
Research Category
Cell Structure
Cell Structure
Research Sub Category
MMPs & TIMPs
MMPs & TIMPs
联系
Replaces: MAB13448
外形
Format: Purified
Purified from ascites fluid by Protein A chromatography. 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.
储存及稳定性
Antibody with sodium azide is stable for 12 months after date of receipt when stored at 2-8°C.
分析说明
Control
POSITIVE CONTROL:
Pancreatic or colon carcinoma
POSITIVE CONTROL:
Pancreatic or colon carcinoma
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Davide Visigalli et al.
BMC cancer, 9, 59-59 (2009-02-20)
The COOH terminal peptide of Pro-collagen type I (PICP, also called C3) is chemotactic for endothelial melanoma and breast cancer cells. PICP induces the expression of Metalloproteinases-2 and -9, of Vascular endothelial growth factor and of the chemokine CXCL-12 receptor
Feng-Cheng Pai et al.
Cells, 10(10) (2021-10-24)
Malignant glioma is one of the most lethal cancers with rapid progression, high recurrence, and poor prognosis in the central nervous system. Fatty acid-binding protein 6 (FABP6) is a bile acid carrier protein that is overexpressed in colorectal cancer. This
Jaqueline J Muniz et al.
Canadian journal of physiology and pharmacology, 96(3), 266-274 (2017-08-19)
We evaluated the effects of ethanol consumption on the mitogen-activated protein kinases (MAPK) and metalloproteinases (MMP) pathways in the rat cavernosal smooth muscle (CSM). Male Wistar rats were treated with ethanol (20% v/v) for 6 weeks. Quantitative real-time polymerase chain
Repeated autologous bone marrow-derived mesenchymal stem cell injections improve radiation-induced proctitis in pigs.
Linard, C; Busson, E; Holler, V; Strup-Perrot, C; Lacave-Lapalun, JV; Lhomme, B; Prat et al.
Stem Cells Translational Medicine null
Histological, histochemical, and protein changes after induced malocclusion by occlusion alteration of Wistar rats.
Guerra, Cde S; Carla Lara Pereira, Y; Issa, JP; Luiz, KG; Guimar?es, EA; Gerlach, RF; Iyomasa, MM
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