推荐产品
生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
liquid
包含
≤0.1% sodium azide as preservative
种属反应性
human
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
同位素/亚型
IgG
运输
wet ice
储存温度
2-8°C
靶向翻译后修饰
unmodified
基因信息
human ... ST14(6768)
一般描述
Immunoaffinity purified rabbit polyclonal antibody. Recognizes the ~75 kDa matriptase protein.
Recognizes the ~75 kDa matriptase protein in MCF-7 cells.
This Anti-Matriptase/MT-SP1 Rabbit pAb is validated for use in Immunoblotting, Immunoprecipitation for the detection of Matriptase/MT-SP1.
免疫原
Human
a synthetic peptide corresponding to amino acids near the C-terminus of human matriptase
应用
Immunoblotting (1:500-1:2000)
Immunoprecipitation (5-20 g/mg lysate)
包装
Please refer to vial label for lot-specific concentration.
警告
Toxicity: Highly Toxic (H)
外形
In Tris-citrate/phosphate buffer, pH 7.0-8.0.
重悬
Following initial use, aliquot and freeze (-20°C) for long-term storage. Avoid freeze/thaw cycles.
分析说明
Positive Control
MCF-7 cells
MCF-7 cells
其他说明
Antibody should be titrated for optimal results in individual systems.
Santin, A.D., et al. 2003. Cancer98, 1898.
Takeuchi, T., et al. 2000. J. Biol. Chem.275, 26333.
Lin, C.Y., et al. 1999. J. Biol. Chem.274, 18231.
Takeuchi, T., et al. 1999. Proc. Natl. Acad. Sci. USA96, 11054.
Takeuchi, T., et al. 2000. J. Biol. Chem.275, 26333.
Lin, C.Y., et al. 1999. J. Biol. Chem.274, 18231.
Takeuchi, T., et al. 1999. Proc. Natl. Acad. Sci. USA96, 11054.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Stine Friis et al.
The Journal of biological chemistry, 286(7), 5793-5802 (2010-12-15)
The matriptase-prostasin proteolytic cascade is essential for epidermal tight junction formation and terminal epidermal differentiation. This proteolytic pathway may also be operative in a variety of other epithelia, as both matriptase and prostasin are involved in tight junction formation in
Sine Godiksen et al.
PloS one, 8(10), e77146-e77146 (2013-11-10)
Matriptase is a member of the family of type II transmembrane serine proteases that is essential for development and maintenance of several epithelial tissues. Matriptase is synthesized as a single-chain zymogen precursor that is processed into a two-chain disulfide-linked form
Sine Godiksen et al.
The Biochemical journal, 413(2), 251-259 (2008-04-12)
HAI-1 [HGF (hepatocyte growth factor) activator inhibitor-1] is a Kunitz-type transmembrane serine protease inhibitor that forms inhibitor complexes with the trypsin-like serine protease, matriptase. HAI-1 is essential for mouse placental development and embryo survival and together with matriptase it is
Ke-Hung Tsui et al.
Journal of molecular endocrinology, 49(2), 153-163 (2012-08-09)
Growth differentiation factor-15 (GDF15), a member of the transforming growth factor-β superfamily, is associated with human cancer progress. We evaluated the role GDF15 plays in tumorigenesis of prostate carcinoma PC-3 cells. Results from real-time RT-PCR and ELISA revealed that expression
Ki Yeon Kim et al.
Journal of experimental & clinical cancer research : CR, 38(1), 363-363 (2019-08-21)
In order to develop a new immunotherapeutic agent targeting metastatic breast cancers, we chose to utilize autocatalytic feature of the membrane serine protease Prss14/ST14, a specific prognosis marker for ER negative breast cancer as a target molecule. The study was
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