一般描述
300单位/mg最小值，50,000单位/瓶。适用于生物化学级。
质量标准：活性：300NF U/mg min
仅用于实验室和生产。不得用于药物、食物或家庭用途。
质量标准：活性：300NF U/mg min
仅用于实验室和生产。不得用于药物、食物或家庭用途。
应用
透明质酸酶已用于：
- 酶法去除细胞外基质（(ECM）以评估突触α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体（AMPAR）的 侧向扩散
- 研究4-甲基伞形酮（4MU）/透明质酸酶（HLX）介导的CD44/透明质酸复合物的消耗对乳腺癌异种移植物中曲妥单抗结合的影响
- 作为Hank 平衡盐溶液（HBSS）培养基的成分用于消化胚胎肠组织
生化/生理作用
透明质酸酶是一种糖苷内切酶，可分解细胞外基质的成分透明质酸（HA）。它用于改善药物扩散，并逆转HA填料注射剂（filler injection）的作用。透明质酸酶可溶解皮下结节，并可修正过量的注射填料。它可以消除胞浆内精子注射过程中形成的卵冠丘复合体。透明质酸酶可抑制多种物质溢出以后导致的组织损伤。它用于减少水肿治疗玻璃体积血。
单位定义
一个单位是基于与每个批次同时测定的内标物在540 nm处的吸光度（浊度）的变化。内标替代USP/NF参考不再可用。
外形
透析的冻干粉末，每毫克（干重）不少于300单位。
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险声明
预防措施声明
危险分类
Resp. Sens. 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Maurizio Cavallini et al.
Aesthetic surgery journal, 33(8), 1167-1174 (2013-11-08)
Hyaluronidases, a family of enzymes that are able to degrade hyaluronic acid (HA), are employed in medicine to increase drug diffusion and reverse the effects of HA filler injections. Hyaluronidases are able to dissolve subcutaneous nodules or to correct excessive
Sang Hak Lee et al.
eLife, 6 (2017-07-28)
Previous studies tracking AMPA receptor (AMPAR) diffusion at synapses observed a large mobile extrasynaptic AMPAR pool. Using super-resolution microscopy, we examined how fluorophore size and photostability affected AMPAR trafficking outside of, and within, post-synaptic densities (PSDs) from rats. Organic fluorescent
Alexander D B Ross et al.
STAR protocols, 2(2), 100597-100597 (2021-06-26)
Here, we describe protocols for the preparation and dissociation of human fetal and pediatric intestinal tissue to a high-viability epithelial single-cell suspension. This epithelium-enriched single-cell suspension can then be used to generate single-cell RNA sequencing data as well as to
Patricia M R Pereira et al.
Molecular pharmaceutics, 17(1), 327-337 (2019-12-06)
Human epidermal growth factor receptor 2 (HER2) is a biomarker in breast cancer, and its overexpression is required to initiate therapies using HER2-targeted antibodies. Although trastuzumab is one of the most effective therapeutic antibodies in HER2-overexpressing breast cancer, a significant
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