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HTMP2MAG-54K

Millipore

MILLIPLEX® Human TIMP磁珠板2-免疫学多重检测试剂

TIMP Bead-Based Multiplex Assays using the Luminex technology enables the simultaneous analysis of multiple TIMP biomarkers in human cell/tissue culture supernatant samples.

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About This Item

UNSPSC代码:
12161503
eCl@ss:
32161000
NACRES:
NA.84

质量水平

200

种属反应性

human

制造商/商品名称

Milliplex®

assay range

accuracy: 77-95%
standard curve range: 10-10,000 pg/mL
(TIMP-4)
standard curve range: 20-20,000 pg/mL
(TIMP-1)
standard curve range: 49-50,000 pg/mL
(TIMP-2)
standard curve range: 98-100,000 pg/mL
(TIMP-3)

技术

multiplexing: suitable

检测方法

fluorometric (Luminex xMAP)

运输

wet ice

相关类别

一般描述

金属蛋白酶（TIMP）的组织抑制剂包括一个四种抑制剂家族，分别称为TIMP-1，TIMP-2，TIMP-3和TIMP-4。TIMP家族的每个成员都有其独特的金属蛋白酶抑制作用。基质金属蛋白酶（MMPs）是锌蛋白酶家族，在正常的生理过程中参与细胞外基质（ECM）的分解，例如胚胎发育，组织和骨骼重塑，伤口愈合，组织形态发生，血管生成和肿瘤转移。还已知MMPs参与细胞表面受体的裂解，凋亡配体（例如FAS配体）的释放，细胞增殖，分化和趋化因子的激活。MMPs的正常功能必须通过其内源性蛋白抑制剂TIMPs精确调节。TIMP通过与MMP形成1：1非共价复合物来抑制MMP，从而阻断底物进入MMP催化位点。除抑制活性MMPs外，TIMPs还具有其他几种生化和生理/生物学功能，例如proMMP激活，促进细胞生长，基质结合，抑制血管生成和诱导细胞凋亡。MMP/TIMP平衡的破坏可导致严重的疾病，例如关节炎，心血管疾病，肿瘤生长和转移。

MILLIPLEX ®人TIMP面板2磁珠试剂盒（TIMP-1、-2、-3、-4）设计用于组织/细胞培养样品。

Luminex® xMAP®平台使用磁珠免疫分析格式，以实现理想的速度和灵敏度，同时定量多种分析物，从而显著提高生产力，同时节省宝贵的样品量。

面板类型：细胞因子/趋化因子

特异性

交叉反应性
在该面板中的分析物之间未观察到显著的交叉反应性。

应用

  • 分析物：TIMP-1、TIMP-2、TIMP-3、TIMP-4
  • 推荐的样品类型：组织和细胞培养物上清液
  • 分析运行时间：一日或过夜
  • 研究类别：炎症 & 免疫学

特点和优势

通过在此面板中选择可用的分析物来设计多重试剂盒。

储存及稳定性

试剂盒组分建议的存储温度为2-8°C。

其他说明

灵敏度：有关单个分析物的灵敏度，请参阅试剂盒方案。

法律信息

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

象形图

Exclamation markEnvironment
GHS07,GHS09

警示用语：

Warning

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

靶器官

Respiratory system

储存分类代码

10 - Combustible liquids

法规信息

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Abstracts from the 43rd American Society of Andrology Annual Meeting, 21-24 April 2018, Portland, Oregon.
Andrology, 6 Suppl 1, 1-98 (2018-03-28)
Larissa Berloffa Belardin et al.
Scientific reports, 9(1), 903-903 (2019-01-31)
Matrix Metalloproteinases (MMPs) and their regulators - Tissue Inhibitors of Matrix Metalloproteinases (TIMPs) - participate in extracellular matrix remodeling, fibrosis, and semen liquefaction, as well as to inflammatory activity. Seminal plasma has been shown to contain MMPs (MMP-2 and MMP-9)
Jonathan H Soslow et al.
Journal of cardiac failure, 25(4), 259-267 (2019-02-15)
Cardiomyopathy is the leading cause of death in Duchenne muscular dystrophy (DMD). Standard cardiac biomarkers are poor indicators of DMD cardiovascular disease. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) regulate collagen turnover. Given the cardiac fibrosis seen in
Julia E Herrmann et al.
Toxicology and applied pharmacology, 274(2), 302-312 (2013-11-30)
Human response to isoproterenol induced cardiac injury was evaluated by gene and protein pathway changes in human heart slices, and compared to rat heart slices and rat heart in vivo. Isoproterenol (10 and 100μM) altered human and rat heart slice
Preethi Vijayaraj et al.
Cell reports, 29(11), 3488-3505 (2019-12-12)
Progressive organ fibrosis accounts for one-third of all deaths worldwide, yet preclinical models that mimic the complex, progressive nature of the disease are lacking, and hence, there are no curative therapies. Progressive fibrosis across organs shares common cellular and molecular

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