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HSP1MAG-63K

Millipore

MILLIPLEX®人脓毒症磁珠板1-免疫应答多重测定

Inflammation/Immunology Bead-Based Multiplex Assays using the Luminex technology enables the simultaneous analysis of multiple sepsis biomarkers in human serum, plasma and cell culture samples.

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About This Item

UNSPSC代码:
12161503
eCl@ss:
32161000
NACRES:
NA.84

质量水平

200

种属反应性

human

制造商/商品名称

Milliplex®

assay range

accuracy: 111%
(sVCAM-1)
accuracy: 114%
(MIF)
accuracy: 98%
(sFas)
standard curve range: 12-50,000 pg/mL
(sFas, sFasL, and PAI-1)
standard curve range: 61-250,000 pg/mL
(sVCAM-1 and sICAM-1)

技术

multiplexing: suitable

检测方法

fluorometric (Luminex xMAP)

运输

wet ice

相关类别

一般描述

脓毒症或SIRS（全身性炎症反应综合征）是由感染引起的，无论是细菌，病毒，真菌还是寄生虫。根据美国疾病预防控制中心（CDC）的数据，脓毒症是美国非冠状动脉ICU患者死亡的第二大主要原因。脓毒症的发病机理非常复杂。对感染的先天和获得性免疫应答都会通过增加免疫抑制的细胞因子表达的变化来中断内稳态。此外，发炎组织中白细胞的迁移分泌组织因子，导致凝血酶的形成，也触发趋化因子和粘附分子通过内皮细胞的释放。当一个或多个器官的低血压或灌注不足导致器官功能障碍时，就会发生严重的脓毒症，进而引起感染性休克，多器官功能障碍综合征（MODS）和死亡。

MILLIPLEX®人脓毒症检测试剂盒1用于同时定量人血清、血浆和细胞/组织培养上清液样品中以下分析物的任何或全部：sFas/TNFRSF6、sFasL、sICAM-1、MIF、PAI-1（总计）、sVCAM-1。该试剂盒采用96孔格式，包含冻干标准混合物、两个内部检测质控品，可最多可测定38份样品，重复两次。

Luminex® xMAP®平台使用磁珠免疫分析格式，以实现理想的速度和灵敏度，同时定量多种分析物，从而显著提高生产力，同时节省宝贵的样品量。

面板类型：免疫反应

应用

  • 分析物：MIF、PAI-1（总计）、sFas、sFasL、sICAM-1、sVCAM-1
  • 推荐样品类型：血清，血浆，组织培养或匀浆
  • 推荐的样品稀释度：血清/血浆1：10
  • 分析运行时间：过夜
  • 研究类别：炎症 & 免疫学

特点和优势

通过在此面板中选择可用的分析物来设计多重试剂盒。

其他说明

灵敏度：有关个体灵敏度，请参阅试剂盒方案。
标准曲线范围：参见QC分析表了解确切浓度（MIF）。

法律信息

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

象形图

Exclamation markEnvironment
GHS07,GHS09

警示用语：

Warning

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

靶器官

Respiratory system

储存分类代码

10 - Combustible liquids

法规信息

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Sigita Kazune et al.
Critical care (London, England), 23(1), 311-311 (2019-09-13)
In patients with septic shock, the skin is often chosen for the evaluation of peripheral perfusion and oxygenation. Changes in skin microcirculatory vessel oxygen saturation and relative hemoglobin concentration can be described using a mottling score or captured with hyperspectral
Dai Kimura et al.
Frontiers in pediatrics, 4, 31-31 (2016-04-12)
Lung injury activates multiple pro-inflammatory pathways, including neutrophils, epithelial, and endothelial injury, and coagulation factors leading to acute respiratory distress syndrome (ARDS). Low-dose methylprednisolone therapy (MPT) improved oxygenation and ventilation in early pediatric ARDS without altering duration of mechanical ventilation
Sonia Y Velásquez et al.
The Journal of biological chemistry, 291(25), 12960-12977 (2016-04-30)
Natural killer (NK) cells induce apoptosis in infected and transformed cells and are important producers of immunoregulatory cytokines. Therefore, they operate under low oxygen conditions (hypoxia) in inflammatory and tumor environments. In vitro studies of NK cells are, however, commonly
Miša Korva et al.
Viruses, 11(8) (2019-07-31)
Hemorrhagic fever with renal syndrome (HFRS) and Crimean-Congo hemorrhagic fever (CCHF) are important viral hemorrhagic fevers (VHF), especially in the Balkan region. Infections with Dobrava or Puumala orthohantavirus and Crimean-Congo hemorrhagic fever orthonairovirus can vary from a mild, nonspecific febrile

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