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HSCRMAG-32K

Millipore

MILLIPLEX®人可溶性细胞因子受体板-免疫学多重检测试剂盒

Simultaneously analyze multiple cytokine and chemokine biomarkers with Bead-Based Multiplex Assays using the Luminex technology, in human serum, plasma and cell culture samples.

别名:

Human Cytokine Receptor Multiplex Kit, Luminex® Human Cytokine Receptor Immunoassay, Millipore Cytokine Receptor Panel

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About This Item

UNSPSC代码:
12161503
eCl@ss:
32161000
NACRES:
NA.84

质量水平

200

种属反应性

human

制造商/商品名称

Milliplex®

assay range

accuracy: 91-104%
sensitivity: 4-208 pg/mL
(Overnight Incubation minDC)
standard curve range: 12.2-50,000 pg/mL
(sIL-4R, sIL-6R, sRAGE, sTNFRI, sTNFRII)
standard curve range: 122.1-500,000 pg/mL
(sEGFR, sIL-1RII, sVEGF-R1, sVEGF-R2, sVEGF-R3)
standard curve range: 24.4-100,000 pg/mL
(sCD30, sgp130, sIL-1RI, sIL-2Rα)
inter-assay cv: <15%
intra-assay cv: <10%

技术

multiplexing: suitable

检测方法

fluorometric (Luminex xMAP)

运输

wet ice

一般描述

细胞因子受体构成细胞因子生物学的组成部分。与细胞因子一样，细胞因子受体参与了几乎全部疾病状态的正常生理和病理过程。可溶性细胞因子受体天然来自编码膜结合受体的基因，或者是受体本身的直接衍生物。可溶性细胞因子受体参与调节过度的炎症反应和调节免疫事件的发现激发了人们对其作为免疫治疗剂的潜在作用的重大研究兴趣。这些可溶性细胞因子受体中有许多可以抑制其细胞因子配体的结合和生物活性，使其成为非常特异的细胞因子拮抗剂。

MILLIPLEX®人可溶性细胞因子受体检测试剂盒用于同时定量人血清、血浆和细胞/组织培养上清液样品中的14种可溶性细胞因子受体。该试剂盒采用96孔板，包含冻干标准混合物、两个内部检测质控品，可最多可测定38份样品，重复两次。

Luminex® xMAP®平台使用磁珠免疫分析格式，以实现理想的速度和灵敏度，同时定量多种分析物，从而显著提高生产力，同时节省宝贵的样品量。

面板类型：细胞因子/趋化因子

应用

  • 分析物：sCD30，sEGFR，sGP130，sIL-1RI，sIL-1RII，sIL-2Rα，sIL-4R，sIL-6R，sRAGE，sTNFRI，sTNFRII，sVEGFR1，sVEGFR2，sVEGFR3
  • 推荐的样品类型：血清、血浆或组织/细胞裂解物和培养上清液
  • 推荐的样品稀释度：血浆或血清或纯细胞培养上清液的1：5稀释
  • 分析运行时间：过夜
  • 研究类别：炎症 & 免疫学

特点和优势

通过在此面板中选择可用的分析物来设计多重试剂盒。

其他说明

灵敏度：请参阅试剂盒方案了解单个检测试剂盒的灵敏度。
请联系技术服务部进行稀释度线性研究。

法律信息

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

警示用语：

Danger

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

靶器官

Respiratory Tract

储存分类代码

10 - Combustible liquids

WGK

WGK 3

法规信息

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Bryan D Young et al.
International heart journal, 62(5), 1096-1105 (2021-09-22)
While cardiac imaging has improved the diagnosis and risk assessment for cardiac sarcoidosis (CS), treatment regimens have consisted of generalized heart failure therapies and non-specific anti-inflammatory regimens. The overall goal of this study was to perform high-sensitivity plasma profiling of
Ian R Kleckner et al.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 27(12), 4615-4625 (2019-04-03)
A growing body of research suggests that inflammation plays a role in many chemotherapy-related toxicities such as fatigue, anxiety, and neuropathy. Regular exercise can change levels of individual cytokines (e.g., reducing IL-6, increasing IL-10); however, it is not known whether
Wendy Yi-Ying Wu et al.
Cancer medicine, 11(4), 1016-1025 (2022-01-15)
No strong aetiological factors have been established for glioma aside from genetic mutations and variants, ionising radiation and an inverse relationship with asthmas and allergies. Our aim was to investigate the association between pre-diagnostic immune protein levels and glioma risk.
Sandra Hellberg et al.
Cell reports, 16(11), 2928-2939 (2016-09-15)
Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS and has a varying disease course as well as variable response to treatment. Biomarkers may therefore aid personalized treatment. We tested whether in vitro activation of MS patient-derived CD4+ T cells could
Dai Kimura et al.
Frontiers in pediatrics, 4, 31-31 (2016-04-12)
Lung injury activates multiple pro-inflammatory pathways, including neutrophils, epithelial, and endothelial injury, and coagulation factors leading to acute respiratory distress syndrome (ARDS). Low-dose methylprednisolone therapy (MPT) improved oxygenation and ventilation in early pediatric ARDS without altering duration of mechanical ventilation
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