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HNDG2MAG-36K

Millipore

MILLIPLEX® 人神经退行性疾病磁珠板2-神经科学多重分析

The analytes available for this multiplex kit are: α1-Antitrypsin, Complement C4, CRP, MIP-4, PEDF, SAP.

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About This Item

UNSPSC代码:
12161503
eCl@ss:
32161000
NACRES:
NA.84

质量水平

200

种属反应性

human

制造商/商品名称

Milliplex®

assay range

accuracy: 84%
(SAP)
accuracy: 88%
(Complement C4)
accuracy: 92%
(α-1-Antitrypsin)
accuracy: 92%
(PEDF)
accuracy: 95%
(MIP-4)
standard curve range: 0.05-200 ng/mL
(PEDF)
standard curve range: 0.10-50 ng/mL
(CRP)
standard curve range: 0.12-500 ng/mL
(SAP)
standard curve range: 0.24-1,000 ng/mL
(α-1-Antitrypsin)
standard curve range: 0.24-1,000 ng/mL
(Complement C4)
standard curve range: 4.88-20,000 ng/mL
(MIP-4)

技术

multiplexing: suitable

检测方法

fluorometric (Luminex xMAP)

运输

wet ice

相关类别

一般描述

MILLIPLEX®人神经变性微珠检测板2（HNDG2MAG-36K）用于同时定量以下任意组合的分析物：α1-抗胰蛋白酶，补体C4，CRP，MIP-4，PEDF，SAP。

神经退行性疾病是一种以大脑和/或脊髓中神经元或其髓鞘随时间恶化为特征的疾病。这些神经元负责处理感官信息、做出决策和控制运动等日常活动。由于这些细胞不容易再生，因此过度的累积损伤会导致与年龄有关的疾病（例如阿尔茨海默氏′病和帕金森氏′病）以及其他疾病（例如肌萎缩侧索硬化（ALS）和癫痫）。这些疾病在个人和全球范围内都是毁灭性的和昂贵的，并且随着人群人口统计学的不断变化，治疗解决方案至关重要。因此，正在进行研究以鉴定生物标志物，这些生物标志物不仅可以帮助科学家了解神经退行性疾病的发病机理，还可以在症状发作之前识别出患有这些疾病的人，并有可能提供新的治疗工具。

面板类型：神经科学

特异性

交叉反应性
抗体与该面板中任何其他分析物之间的交叉反应性都为无法检测或可忽略。

应用

  • 分析物：α1-抗胰蛋白酶，补体C4，CRP，MIP-4，PEDF，SAP
  • 推荐的样品类型：血清，血浆和CSF
  • 推荐的样品稀释度：1：2,000稀释的血清/血浆或1：20稀释的CSF
  • 分析运行时间：过夜
  • 研究类别：神经科学
  • 研究子类别：阿尔茨海默病神经系统

特点和优势

通过在此面板中选择可用的分析物来设计多重试剂盒。

包装

单个试剂盒即可满足您的所有需求。

储存及稳定性

试剂盒组分建议的存储温度为2-8°C。

其他说明

灵敏度：有关单个灵敏度，请参见试剂盒方案。

法律信息

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

警示用语：

Danger

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

靶器官

Respiratory Tract

储存分类代码

10 - Combustible liquids

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Aziza Al-Rafiah et al.
BioMed research international, 2021, 3081891-3081891 (2021-10-30)
Parkinson's disease (PD) is one of the most common neurodegenerative disorders. Amphetamine addiction may cause serious of psychotic and physical damage to humans. There is some evidence that shows that amphetamine may increase the risk of PD. Thus, this study
Sean J Lee et al.
Journal of clinical & experimental ophthalmology, 6(5) (2016-01-26)
Alterations in neuron-glia signaling are implicated in glaucoma, a neurodegenerative disease characterized by retinal ganglion cell (RGC) death. Pigment epithelium derived factor (PEDF) is a secreted protein with potential neuroprotective qualities in retinal disease, including chronic ocular hypertension. Here we
Abdul Hye et al.
Alzheimer's & dementia : the journal of the Alzheimer's Association, 10(6), 799-807 (2014-07-12)
The study aimed to validate previously discovered plasma biomarkers associated with AD, using a design based on imaging measures as surrogate for disease severity and assess their prognostic value in predicting conversion to dementia. Three multicenter cohorts of cognitively healthy
Felipe Mallmann et al.
Arquivos brasileiros de oftalmologia, 82(4), 275-282 (2019-04-11)
To compare the intravitreal concentrations of cellular mediators involved in neurodegeneration, inflammation, and angiogenesis in patients with proliferative diabetic retinopathy and other vitreoretinal diseases. A multiplex bead immunoassay was used to measure vitreous levels of pigment epithelium-derived factor, serum amyloid
Jinxue Wei et al.
Neuropsychiatric disease and treatment, 14, 37-41 (2018-01-06)
Elevation of plasma inflammatory factors in major depressive disorder (MDD) has been repeatedly observed, but contradictory results have also been reported. Alteration of complement components in MDD may also contribute to the pathophysiology of MDD by participating in inflammation. The
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