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HNDG1MAG-36K

Millipore

MILLIPLEX® 人神经退行性疾病磁珠板1-神经科学多重分析

The analytes available for this multiplex kit are: α2-Macroglobulin, Apo Al, Apo CIII, Apo E, Complement C3 and Complement Factor H.

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About This Item

UNSPSC代码:
12161503
eCl@ss:
32161000
NACRES:
NA.84

质量水平

种属反应性

human

制造商/商品名称

Milliplex®

assay range

accuracy: 105%
(Complement Factor H)

accuracy: 110%
(Apo E)

accuracy: 75%
(Complement C3)

intra-assay cv: <10
standard curve range: 0.01-40 ng/mL
(Apo CIII)

standard curve range: 0.05-200 ng/mL
(Apo E, Complement C3)

standard curve range: 0.3-1,000 ng/mL
(Complement Factor H)

standard curve range: 0.5-2,000 ng/mL
(α-2-Macroglobulin)

standard curve range: 0.7-3,000 ng/mL
(Apo A1)

技术

multiplexing: suitable

检测方法

fluorometric (Luminex xMAP)

运输

wet ice

一般描述

神经退行性疾病是一种以大脑和/或脊髓中神经元或其髓鞘随时间恶化为特征的疾病。这些神经元负责处理感官信息、做出决策和控制运动等日常活动。由于这些细胞不容易再生,因此过度的累积损伤会导致与年龄有关的疾病(例如阿尔茨海默氏′病和帕金森氏′病)以及其他疾病(例如肌萎缩侧索硬化(ALS)和癫痫)。这些疾病在个人和全球范围内都是毁灭性的和昂贵的,并且随着人群人口统计学的不断变化,治疗解决方案至关重要。因此,正在进行研究以鉴定生物标志物,这些生物标志物不仅可以帮助科学家了解神经退行性疾病的发病机理,还可以在症状发作之前识别出患有这些疾病的人,并有可能提供新的治疗工具。
“MILLIPLEX”人神经变性微珠检测板1(HNDG1MAG-36K)将用于同时定量以下7种分析物的任意组合:α-2-巨球蛋白、Apo A1、Apo CIII、Apo E、补体C3和补体因子H。本试剂盒可用于人血清、血浆、脑脊液样本中全部类上述分析物的分析。

面板类型:神经科学

特异性

交叉反应性
抗体与该面板中任何其他分析物之间的交叉反应性都为无法检测或可忽略。

应用

  • 分析物::α2-巨球蛋白,Apo Al,Apo CIII,Apo E,补体C3,补体因子H
  • 推荐的样品类型:血清,血浆和CSF
  • 推荐的样品稀释度:每孔1:40,000稀释的血清/血浆或1:400稀释的CSF
  • 分析运行时间:一天
  • 研究类别:神经科学

特点和优势

通过在此面板中选择可用的分析物来设计多重试剂盒。

包装

单个试剂盒即可满足您的所有需求。

储存及稳定性

试剂盒组分建议的存储温度为2-8°C。

其他说明

灵敏度:单个分析物的灵敏度见方案

法律信息

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

警示用语:

Danger

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

靶器官

Respiratory Tract

储存分类代码

10 - Combustible liquids

法规信息

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Cerebrospinal fluid complement activation in patients with pneumococcal and meningococcal meningitis.
Mook-Kanamori, BB; Brouwer, MC; Geldhoff, M; Ende, Av; van de Beek, D
The Journal of Infection null
William T Hu et al.
Acta neuropathologica communications, 4, 14-14 (2016-02-19)
CSF levels of established Alzheimer's disease (AD) biomarkers remain stable despite disease progression, and non-amyloid non-tau biomarkers have the potential of informing disease stage and progression. We previously identified complement 3 (C3) to be decreased in AD dementia, but this
Abdul Hye et al.
Alzheimer's & dementia : the journal of the Alzheimer's Association, 10(6), 799-807 (2014-07-12)
The study aimed to validate previously discovered plasma biomarkers associated with AD, using a design based on imaging measures as surrogate for disease severity and assess their prognostic value in predicting conversion to dementia. Three multicenter cohorts of cognitively healthy
Maria H Pham et al.
Materials (Basel, Switzerland), 13(3) (2020-02-08)
Immediately after dental implant insertion, blood will be in direct contact and interact with the implant surface and activates inflammatory responses and complement cascades within seconds. The aim of the present study was to determine the ability of fluoride-modified titanium
Zaohuo Cheng et al.
Frontiers in aging neuroscience, 10, 414-414 (2019-01-09)
It is well known that Alzheimer's disease (AD) is one of the most common progressive neurodegenerative diseases; it begins gradually, and therefore no effective medicine is administered in the beginning. Thus, early diagnosis and prevention of AD are crucial. The

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通过适合的免疫检测产品,探索神经免疫和神经炎症细胞因子及神经退行性疾病生物标志物。

查看所有结果

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