跳转至内容
Merck
CN
所有图片(1)

主要文件

查看所有文档

安全信息

HKI1MAG-99K

Millipore

MILLIPLEX® 人肾损伤磁珠板1 - 毒性多重检测

The analytes available for this multiplex kit are: Calbindin, Collagen IV, Fatty Acid Binding Protein 1 (FABP1), GSTα, IP-10, Kidney Injury Molecule-1 (KIM-1), Renin, TFF-3, TIMP-1.

登录查看公司和协议定价
所有图片(1)

About This Item

UNSPSC代码:
12161503
eCl@ss:
32161000
NACRES:
NA.84

质量水平

200

种属反应性

human

制造商/商品名称

Milliplex®

assay range

accuracy: 73-117%
sensitivity: 0.010-6.473 ng/mL
(MinDC = 2SD)
standard curve range: 0.005-5 ng/mL
(IP-10)
standard curve range: 0.02-25 ng/mL
(Renin)
standard curve range: 0.05-50 ng/mL
(GSTα)
standard curve range: 0.05-50 ng/mL
(KIM-1)
standard curve range: 0.10-100 ng/mL
(TIMP-1)
standard curve range: 0.20-200 ng/mL
(Calbindin)
standard curve range: 0.34-350 ng/mL
(Collagen IV)
standard curve range: 0.49-500 ng/mL
(TFF-3)
standard curve range: 5.86-6,000 ng/mL
(FABP1)
inter-assay cv: <15%
intra-assay cv: <10%

技术

multiplexing: suitable

检测方法

fluorometric (Luminex xMAP)

运输

wet ice

一般描述

体内生理性平衡的维持部分归因于正常的肾脏功能。由于损伤，药物毒性或肾衰竭引起的肾脏功能改变可能危及生命。毒性是药物失败的主要原因，因此研究正在扩大，以寻找更灵敏，快速的方法来尽快确定器官特异性损伤。传统上，血尿素氮（BUN）和血清肌酐测试已用于确定药物对肾脏的损害。这些检查仅在开始后检测肾脏损害，无法阐明肾脏损害发生在何处。特异性和肾脏损伤的早期检测至关重要，并且该研究领域正在扩大，以寻找更灵敏，快速的方法来确定肾脏的特定损伤区域。

MILLIPLEX®产品组合提供了有价值的研究分析方法，可以使用Luminex® xMAP®仪器平台研究人类尿液样品中肾脏损伤的多种生物标志物。可用于该多重试剂盒的分析物包括：钙结合蛋白、胶原IV、脂肪酸结合蛋白1（FABP1）、GSTα、IP-10、肾损伤分子-1（KIM-1）、肾素、TFF-3、TIMP-1。

面板类型：毒性

特异性

交叉反应性
对于面板中的一种分析物和任何其他分析物，抗体之间没有或有可以忽略不计的交叉反应性。

应用

  • 分析物：钙结合蛋白、IV型胶原、FABP1、GSTα、IP-10、KIM-1、肾素、TFF-3、TIMP-1
  • 推荐的样品稀释类型：尿
  • 推荐的样品稀释度：1：2试剂盒检测缓冲液客户需要确定其样品的最佳稀释因子。我们的建议基于正常受试者的尿液样品。
  • 分析运行时间：过夜
  • 研究类别：毒性

特点和优势

通过在此面板中选择可用的分析物来设计多重试剂盒。

其他说明

灵敏度：请参阅试剂盒方案了解单个检测试剂盒的灵敏度。

法律信息

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

靶器官

Respiratory Tract

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

法规信息

新产品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Leonardo Trasande et al.
Environmental pollution (Barking, Essex : 1987), 256, 113334-113334 (2019-11-05)
The goal of this study was to assess biomarkers of exposure to glyphosate and assess potential associations with renal function in children. Glyphosate is used ubiquitously in agriculture worldwide. While previous studies have indicated that glyphosate may have nephrotoxic effects
Hui Huang et al.
Journal of translational medicine, 20(1), 102-102 (2022-02-25)
Acute kidney injury (AKI) is associated with high morbidity and mortality. Multiple urinary biomarkers have been identified to be associated with the prediction of AKI and outcomes. However, the accuracy of these urinary biomarkers for AKI and associated outcomes has
Irene Capelli et al.
In vivo (Athens, Greece), 34(3), 1333-1339 (2020-05-02)
Acute kidney injury is an important cause of mortality in very-low-birth-weight (VLBW) preterm infants. As in the general population, the detection of renal damage cannot rely on the measurement of serum creatinine, since it has been demonstrated to be a

相关内容

Nephrotoxicity Analysis with Kidney Toxicity Multiplex Assays | MILLIPLEX® Assays

Novel kidney toxicity biomarkers expand options for acute nephrotoxicity detection. Multiplex assays measure multiple renal damage biomarkers in small sample volumes, minimizing time and costs. See how MILLIPLEX® multiplex kidney toxicity assays detected vancomycin-induced subacute nephrotoxicity in rat models.

Multiplex Toxicity Assays | MILLIPLEX® Assays

Multiplex toxicity assays enable researchers to simultaneously measure multiple toxicity biomarkers of various organs to gain a better understanding of toxicity. Explore how MILLIPLEX® multiplex toxicity assays are advancing research on liver injury, kidney toxicity, genotoxicity, and more.

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门