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安全信息

HGAMMAG-301K

Millipore

MILLIPLEX® 人同分型磁珠板 - 同分型多重检测

Isotyping Bead-Based Multiplex Assays using the Luminex technology enables the simultaneous analysis of multiple immunoglobulins (Ig) in human serum, plasma and cell culture samples.

别名:

Human Ig isotype multiplex panel, Human immune globulin multiplex panel, Human immunoglobulin multiplex kit, Luminex® human immunoglobulin immunoassay, Millipore Human immunoglobulin panel

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About This Item

UNSPSC代码:
12161503
eCl@ss:
32161000
NACRES:
NA.47

质量水平

200

种属反应性

human

制造商/商品名称

Milliplex®

assay range

accuracy: 88-99%
sensitivity: 0.08 ng/mL
(IgG4)
sensitivity: 0.09 ng/mL
(IgG3)
sensitivity: 0.47 ng/mL
(IgM)
sensitivity: 1.5 ng/mL
(IgA)
sensitivity: 10 ng/mL
(IgG1)
sensitivity: 85 ng/mL
(IgG2)
standard curve range: 0.2-150 ng/mL
(IgG3)
standard curve range: 0.4-300 ng/mL
(IgG4)
standard curve range: 14-10,000 ng/mL
(IgG1)
standard curve range: 2.1-1,500 ng/mL
(IgA)
standard curve range: 3.4-2,500 ng/mL
(IgM)
standard curve range: 41-30,000 ng/mL
(IgG2)

技术

multiplexing: suitable

检测方法

fluorometric (Luminex xMAP)

运输

wet ice

相关类别

一般描述

免疫球蛋白（抗体）由浆细胞和淋巴细胞产生，关键地参与免疫反应，附着在抗原上并在其破坏中起作用。免疫球蛋白（Ig）可按同种型进行分类，即由于结构可变性而在功能和抗原反应方面不同的类别。在胎盘哺乳动物中已鉴定出五种主要同种型：IgM、IgG、IgA、IgE和IgD（B细胞受体）- 在正常人中发现的全部。免疫球蛋白缺乏性疾病，如自身免疫性疾病、一些胃肠道疾病和恶性肿瘤，以特定同种型缺陷或一种或多种同种型浓度不同为特征。疾病状态的范围可以从缺乏一种同种型类别或亚类到完全缺乏免疫球蛋白类别。此外，同型分型应用包括在抗体产生和疫苗开发过程中分析杂交瘤。

用于测量人IgG亚类（1、2、3、4）、IgM和IgA的MILLIPLEX®人同种型微珠面板旨在使您能够在一个孔中准确测量类别和亚类-全部。此外，该面板允许您仅选择实验所需的免疫球蛋白。

Luminex® xMAP®平台使用磁珠免疫分析格式，以实现理想的速度和灵敏度，同时定量多种分析物，从而显著提高生产力，同时节省宝贵的样本量。

面板类型：免疫反应

应用

  • 分析物：IgG1, IgG2, IgG3, IgG4, IgA, IgM
  • 推荐样品类型：血清，血浆或组织/细胞裂解物和培养上清液样品
  • 推荐的样本稀释度：1:16,000稀释的血浆或血清，或细胞培养上清液稀释至每孔约1 μg/mL Ig
  • 分析运行时间：一天
  • 研究类别：炎症 & 免疫学

特点和优势

通过在此面板中选择可用的分析物来设计多重试剂盒。

组分

MILLIPLEX MAP 抗人 κ 和 λ 轻链，PE

MILLIPLEX MAP 人多免疫球蛋白标准品

MILLIPLEX MAP 人免疫球蛋白阳性对照

MILLIPLEX MAP 测定缓冲液

MILLIPLEX MAP 洗涤缓冲液，10X

法律信息

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

警示用语：

Danger

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

靶器官

Respiratory Tract

储存分类代码

10 - Combustible liquids

法规信息

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Brian K McFarlin et al.
Journal of dietary supplements, 10(3), 171-183 (2013-08-10)
Strenuous exercise, such as running a marathon, is known to suppress mucosal immunity for up to 24 hr, which can increase the risk of developing an upper respiratory tract infection (URTI) and reduced performance capacity (Allgrove JE, Geneen L, Latif
Jiong Wang et al.
Frontiers in immunology, 12, 696370-696370 (2021-08-14)
The COVID-19 pandemic is caused by SARS-CoV-2, a novel zoonotic coronavirus. Emerging evidence indicates that preexisting humoral immunity against other seasonal human coronaviruses (HCoVs) plays a critical role in the specific antibody response to SARS-CoV-2. However, current work to assess
Rukmani Lekhraj et al.
Scientific reports, 12(1), 6934-6934 (2022-04-29)
The immune system has been described to play a role in the development of Alzheimer's disease (AD), but the distribution of immunoglobulins and their subclasses in brain tissue has not been explored. In this study, examination of pathologically diagnosed frontal
Panagiotis Karagiannis et al.
Oncoimmunology, 4(11), e1032492-e1032492 (2015-10-10)
Emerging evidence suggests pathological and immunoregulatory functions for IgG4 antibodies and IgG4+ B cells in inflammatory diseases and malignancies. We previously reported that IgG4 antibodies restrict activation of immune effector cell functions and impair humoral responses in melanoma. Here, we
B G Jones et al.
Clinical and experimental immunology, 183(2), 239-247 (2015-10-02)
Vitamin A supports the induction of immunoglobulin (Ig)A responses at mucosal surfaces in mice, but much less is known about the influence of vitamins on antibody isotype expression in humans. To address this knowledge gap, we examined 46 residual blood
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