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HCMP2MAG-19K

Millipore

MILLIPLEX® 人补体板2 - 免疫学多重检测

The Human Complement Panel 2 Bead-Based Multiplex Assay kit, using the Luminex xMAP technology, enables the simultaneous analysis of complement proteins and factors in human serum, plasma and cell culture samples.

别名:

Human complement multiplex kit, Luminex® human complement immunoassay, Millipore human complement panel

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About This Item

UNSPSC代码:
12161503
eCl@ss:
32161000
NACRES:
NA.47

质量水平

200

种属反应性

human

制造商/商品名称

Milliplex®

assay range

accuracy: 95%
(Complement C3)
sensitivity: 0.024 ng/mL
(Complement Factor B)
sensitivity: 0.048 ng/mL
(Complement C1q)
sensitivity: 0.120 ng/mL
(Complement C3)
sensitivity: 0.135 ng/mL
(Complement Factor H)
sensitivity: 0.191 ng/mL
(Complement C4)
sensitivity: 3.639 ng/mL
(Complement C3b/iC3b)
standard curve range: 0.041-300 ng/mL
(Complement Factor H)
standard curve range: 0.08-60 ng/mL
(Complement C1q)
standard curve range: 0.08-60 ng/mL
(Complement Factor B)
standard curve range: 0.27-200 ng/mL
(Complement C3)
standard curve range: 0.55-400 pg/mL
(Complement C4)

技术

multiplexing: suitable

检测方法

fluorometric (Luminex xMAP)

运输

ambient

一般描述

补体系统由大量血浆蛋白组成蛋白，这些蛋白有助于吞噬细胞和抗体清除病原体的能力。有三种不同的同时途径。经典途径由抗原-抗体复合物刺激；替代途径在与致病细胞表面接触时自发激活；甘露糖结合凝集素（MBL）途径识别通常仅存在于致病细胞表面的甘露糖。由于可能对宿主组织造成极大损害，因此必须严格控制补体系统的激活。调节补体控制蛋白（包括CD59，也称为保护素）在血液血浆中的浓度高于补体蛋白本身。补体系统被认为在许多具有免疫成分的疾病中起关键作用，例如哮喘和许多自身免疫性疾病，包括SLE，IBD和多发性硬化。它也越来越多地与神经系统疾病（例如阿尔茨海默氏病）和诸如脊髓损伤之类的疾病相关。

MILLIPLEX®补体面板2珠面板是一种6重试剂盒，用于同时定量血清、血浆或培养上清液样品中以下任何或所有分析物：C1q、C3、C3b/iC3b、C4、补体因子B、补体因子H和备解素。

Luminex® xMAP®平台使用磁珠免疫分析格式，以实现理想的速度和灵敏度，同时定量多种分析物，从而显著提高生产力，同时节省宝贵的样本量。

面板类型：免疫反应

特异性

交叉反应性
抗体与该面板中任何其他分析物之间的交叉反应性都为无法检测或可忽略。

应用

  • 分析物：C1q、C3、C3b/iC3b、C4、因子B、因子H
  • 推荐的样品类型：血清，血浆和组织/细胞培养上清液
  • 推荐的样品稀释度：1:40,000稀释的血浆或血清。组织培养上清液可能需要在测定之前用适当的对照培养基稀释
  • 分析运行时间：过夜或2小时初次孵育
  • 研究类别：炎症 & 免疫学
  • 研究子类别：炎症
  • 注释：为避免样品中的补体激活（这将影响结果），应尽快解冻样品，置于冰上并立即进行分析

特点和优势

通过在此面板中选择可用的分析物来设计多重试剂盒。

包装

96孔板

储存及稳定性

试剂盒组分建议的存储温度为2-8°C。

法律信息

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

警示用语：

Danger

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

靶器官

Respiratory Tract

储存分类代码

10 - Combustible liquids

法规信息

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Pavan Bhargava et al.
Multiple sclerosis (Houndmills, Basingstoke, England), 27(4), 509-518 (2020-07-17)
Synaptic loss is a feature of multiple sclerosis pathology that can be seen even in normal-appearing gray matter. Opsonization of synapses with complement components may underlie pathologic synapse loss. We sought to determine whether circulating neuronal-enriched and astrocytic-enriched extracellular vesicles
Manjunath Ramanjaneya et al.
Frontiers in endocrinology, 12, 740703-740703 (2022-03-08)
The complement system is pivotal in host defense mechanisms, protecting against pathogenic infection by regulating inflammation and cell immunity. Complement-related protein activation occurs through three distinct pathways: classical, alternative, and lectin-dependent pathways, which are regulated by cascades of multiple proteins.
Manjunath Ramanjaneya et al.
Frontiers in endocrinology, 12, 641361-641361 (2021-04-17)
Gestational Diabetes Mellitus (GDM) development is related to underlying metabolic syndrome that is associated with elevated complement C3 and C4. Elevated C3 levels have been associated with preeclampsia and the development of macrosomia. This case-control study included 34 pregnant women
Milla R McLean et al.
Clinical & translational immunology, 10(11), e1355-e1355 (2021-11-13)
Tuberculosis comorbidity with chronic diseases including diabetes, HIV and chronic kidney disease is of rising concern. In particular, latent tuberculosis infection (LTBI) comorbidity with end-stage kidney disease (ESKD) is associated with up to 52.5-fold increased risk of TB reactivation to
Shamma Al-Muraikhy et al.
Frontiers in molecular biosciences, 8, 715035-715035 (2021-10-12)
Introduction: Aerobic exercise activates the complement system in the peripheral blood. However, the effect of age and high intensity endurance training on the levels of circulating complements and sassociated inflammatory cytokines, oxidative stress markers and cellular aging remains unknown. Methods:
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