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Merck
CN

HAIAB-10K

MILLIPLEX® 人类自身免疫自身抗体Panel

Configurable Human Autoimmune Autoantibody IgG 20-Plex Panel, Milliplex®

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关于此项目

UNSPSC Code:
12161503
NACRES:
NA.47
eCl@ss:
32161000
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产品名称

MILLIPLEX® 人类自身免疫自身抗体Panel, Configurable Human Autoimmune Autoantibody IgG 20-Plex Panel, Milliplex®

quality

100

species reactivity

human

manufacturer/tradename

Milliplex®

packaging

1 ea of

technique(s)

multiplexing: suitable

input

serum plasma

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

Biochem/physiol Actions

交叉反应
样品孵育过程中不含抗原、无关抗原或特异性抗原。 与特定抗原一起孵育可导致反应性选择性丧失,而反应性不受无关抗原的影响。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Features and Benefits

从该组套选择可用的分析物来设计多重试剂盒。

General description

自身抗体的形成是多种自身免疫性疾病发病的主要原因。细胞凋亡失调和随后的细胞碎片清除缺陷导致自身抗原的暴露和自身抗体的产生。自身抗体的存在可能表明疾病活动性、预后以及与多种自身免疫性疾病相关的临床关联。这些自身免疫性疾病包括但不限于Sjögren综合征、系统性红斑狼疮、混合性结缔组织病、系统性硬化症、CREST综合征、多发性肌炎/皮肌炎、血管炎、抗磷脂综合征以及这些疾病的各种重叠综合征。

MILLIPLEX® 人自身免疫抗体磁珠Panel是一款20重试剂盒,可同时检测和分析血清和血浆样品中的以下任何或所有分析物:抗C1q、抗着丝粒蛋白A(CENP-A)、抗着丝粒蛋白B(CENP-B)、抗β 2-糖蛋白、抗Jo-1、抗Ku、抗Mi-2、抗髓过氧化物酶、抗增殖细胞核抗原A(PCNA)、抗丙氨酰tRNA合成酶(PL-12)、抗PM/Scl-100、抗蛋白酶3、抗核糖体P、抗核糖核蛋白(RNP)、抗RNP/Smith(RNP/Sm)、抗Scl-70、抗Sm、抗Sjögren综合征相关抗原B/La(SSB/La)、抗Sjögren综合征相关抗原A/Ro52 kDa(SSA/Ro52)、抗Sjögren综合征相关抗原A/Ro60 kda(SSA/Ro60)。该Panel的基础试剂盒包含4种检测对照磁珠。从单一到多重生物标记物解决方案,我们与您合作,设计、开发、分析验证和建立可用于自身抗体检测的最全面抗体库。

面板类型:免疫反应
Autoantibody formation is principal to the pathogenesis of a variety of autoimmune diseases. Dysregulated apoptosis and the subsequent defective clearance of cellular debris leads to the exposure of autoantigens and the generation of autoantibodies. The presence of autoantibodies may indicate disease activity, prognosis, and clinical associations related to a variety of autoimmune diseases. These autoimmune diseases include, but are not limited to, Sjögren′s Syndrome, Systemic Lupus Erythematosus, Mixed Connective Tissue Disease, Systemic Sclerosis, CREST syndrome, Polymyositis/Dermatomyositis, Vasculitis, Anti-Phospholipid Syndrome, and various overlap syndromes of these diseases.

Packaging

96 well plate
单个试剂盒即可满足您的所有需求。

Preparation Note

试剂盒组分建议储存于2 - 8°C。

Legal Information

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
Luminex is a registered trademark of Luminex Corp
xMAP is a registered trademark of Luminex Corp

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 20 analytes in human serum and plasma samples.Analytes included: β2-Glycoprotein, C1q, CENP-B (Centromere Protein B), CENP-A (Centromere Protein A), Jo-1, Ku, Mi-2, Myeloperoxidase (MPO), PCNA (Proliferating Cell Nuclear Antigen A), PL-12 (Alanyl-tRNA synthetase), PM/Scl 100, Proteinase 3, RNP (Ribonucleoprotein), RNP/Smith (RNP/Sm), Ribosomal P, Scl-70, Sm, SSB/La (Sjögren′s Syndrome-related antigen B/La), SSA/Ro60 (Sjögren′s Syndrome-related antigen A/Ro60 kDa), SSA/Ro52 (Sjögren′s Syndrome-related antigen A/Ro52 kDa)Note: This is a qualitative assay.Assay Characteristics: Refer to kit protocol for assay cross-reactivity and precision.

pictograms

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Warning

Hazard Classifications

Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1

存储类别

12 - Non Combustible Liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

wgk

WGK 3

法规信息

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Dan Li et al.
JCI insight, 5(2) (2019-12-27)
Genetic variants within or near the interferon regulatory factor 5 (IRF5) locus associate with systemic lupus erythematosus (SLE) across ancestral groups. The major IRF5-SLE risk haplotype is common across populations, yet immune functions for the risk haplotype are undefined. We
Jieun Kwon et al.
The ocular surface, 18(1), 80-97 (2019-10-14)
To investigate the role of Anti-Citrullinated Protein autoantibodies (ACPAs) in the pathology of dry eye disease (DED) and the therapeutic potential of pooled human immune globulin-eye drops in these patients. We investigated the presence of citrullinated proteins and ACPAs in

相关内容

Immunology multiplex assays, like MILLIPLEX® assays, allow researchers to investigate more immune biomarkers simultaneously, saving time and resources.

Multiplex analysis of autoantibodies, such as MILLIPLEX® multiplex assays, helps advance research by detecting multiple autoantibodies like cytokine autoantibodies, autoimmune autoantibodies, and cancer autoantibodies at once to give researchers a full picture of analyte concentrations.

MILLIPLEX® multiplex assays provide a comprehensive catalog of biomarkers, offering unique analytes not available from other Luminex® assay suppliers.

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