Milli-Mark^®Anti-Cytokeratin 5 Antibody, 6-FITC, clone D5/16B4

The cytokeratins are a family of intermediate filaments found in almost all epithelial cells. They are divided into four subclasses depending on their patterns of reactivity and electrophoretic characteristics and are also arranged I a numbered series of 20 or more acoring to molecular weight and isoelectric point (Quinlan et al. 1985). Types 5 and 6 of cytokeratin (CK5/6) are in high frequency in mesothelial cells, as opposed to cells of adenocarcinoma. CK5/6 has been shown to be a reliable marker for mesothelioma and squamous cell carcinoma of the lung and Bowen′s disease. It does not react with pulmonary adenocarcinoma.

Antibody recognizes Human Cytokeratin.

Purified cytokeratin 5 (Wild, 1986) (Mischke, 1987).

Milli-MarkAnti-Cytokeratin 5 Antibody, 6-FITC, clone D5/16B4 is an antibody against Cytokeratin 5 for use in FC.

Research Category
Cell Structure

Research Sub Category
Cytoskeleton

Evaluated by flow cytometry using A431 cells

The calculated for Cytokeratin is 62 kDa, however, different isoforms state Cytokeratin 4 (59 kDa), Cytokeratin 5 (58 kDa) and Cytokeratin 6 (56 kDa).

Protein A purified

Purified mouse monoclonal IgG1 conjugated to FITC in PBS buffer with 15mg/mL BSA and sodium azide at 0.1%.

Maintain refrigerated at 2-8°C protected from light for up to 6 months from date of receipt.

Control
A431 cells

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