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Milli-Mark^® 抗-FcεRI抗体，γ 亚基-FITC

Name: Milli-Mark<SUP>®</SUP> 抗-FcεRI抗体，γ 亚基-FITC
Brand: MM

Milli-Mark^®, from rabbit

别名:

Fc fragment of IgE high affinity I receptor for gamma polypeptide, Fc-epsilon RI-gamma, FceRI gamma, IgE Fc receptor subunit gamma, Immunoglobulin E receptor, high affinity,gamma chain

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About This Item

UNSPSC代码:

12352203

eCl@ss:

32160702

NACRES:

NA.41

生物来源

rabbit

质量水平

100

偶联物

FITC conjugate

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

polyclonal

种属反应性

mouse, human, rat

制造商/商品名称

Milli-Mark^®

技术

flow cytometry: suitable

同位素/亚型

IgG

NCBI登记号

NP_004097

UniProt登记号

P30273

运输

wet ice

靶向翻译后修饰

unmodified

基因信息

human ... FCER1G(2207)

一般描述

I型过敏反应是通过IgE高亲和受体（FceRI）介导的。当呈递多价抗原时，单体IgE FceRI受体复合物的重新分布会导致肥大细胞和嗜碱性粒细胞脱粒，从而导致随后释放引起I型过敏反应的因子。FceRI受体是四聚体复合物，由a链，b链和二聚体g链组成。尽管a链主要参与IgE的结合，但信号通过g亚基转移，g亚基包含免疫受体酪氨酸激活基序（ITAM），对于通过Syk和Lyn酪氨酸激酶启动受体介导的信号转导至关重要。FceRI受体能够与IgE结合和脱离，为研究激酶偶联受体的性能提供了通用模型。

特异性

可识别并特异于FcεRI，γ-亚基。

免疫原

与Fc受体γ亚基的80-86氨基酸对应的合成肽。

应用

Milli-Mark 抗-FcεRI抗体，γ亚基-FITC是针对FcεRI的抗体，用于FC。

研究子类别
炎症 & 自身免疫机制

研究类别
炎症 & 免疫学

质量

通过流式细胞术对RBL细胞进行了评估

目标描述

计算值为10 kDa

外形

在含0.1％叠氮化钠和15 mg/mL BSA的PBS中与FITC偶联的纯化的兔多克隆IgG。

纯化的蛋白 A

储存及稳定性

自收到之日起，未稀释等分试样避光冷藏于 2-8°C，可保存6个月。

分析说明

对照
RBL细胞

其他说明

已证明非偶联抗体（目录编号06-727）对人和小鼠有效。

最佳工作稀释度必须由其它仪器的最终用户进行确定。

法律信息

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Human Cytomegalovirus Infection Promotes Expansion of a Functionally Superior Cytoplasmic CD3+ NK Cell Subset with a Bcl11b-Regulated T Cell Signature.

Zeguang Wu et al.

Journal of immunology (Baltimore, Md. : 1950), 207(10), 2534-2544 (2021-10-10)

Human CMV (HCMV) is a ubiquitous pathogen that indelibly shapes the NK cell repertoire. Using transcriptomic, epigenomic, and proteomic approaches to evaluate peripheral blood NK cells from healthy human volunteers, we find that prior HCMV infection promotes NK cells with

Ablation of SYK Kinase from Expanded Primary Human NK Cells via CRISPR/Cas9 Enhances Cytotoxicity and Cytokine Production.

James D Dahlvang et al.

Journal of immunology (Baltimore, Md. : 1950), 210(8), 1108-1122 (2023-03-08)

CMV infection alters NK cell phenotype and function toward a more memory-like immune state. These cells, termed adaptive NK cells, typically express CD57 and NKG2C but lack expression of the FcRγ-chain (gene: FCER1G, FcRγ), PLZF, and SYK. Functionally, adaptive NK

Tumor-Targeting Anti-CD20 Antibodies Mediate In Vitro Expansion of Memory Natural Killer Cells: Impact of CD16 Affinity Ligation Conditions and In Vivo Priming.

Cristina Capuano et al.

Frontiers in immunology, 9, 1031-1031 (2018-06-06)

Natural killer (NK) cells represent a pivotal player of innate anti-tumor immune responses. The impact of environmental factors in shaping the representativity of different NK cell subsets is increasingly appreciated. Human cytomegalovirus (HCMV) infection profoundly affects NK cell compartment, as

CMV Primes Functional Alternative Signaling in Adaptive Δg NK Cells but Is Subverted by Lentivirus Infection in Rhesus Macaques.

Spandan V Shah et al.

Cell reports, 25(10), 2766-2774 (2018-12-06)

Despite burgeoning evidence demonstrating the adaptive properties of natural killer (NK) cells, mechanistic data explaining these phenomena are lacking. Following antibody sensitization, NK cells lacking the Fc receptor (FcR) signaling chain (Δg) acquire adaptive features, including robust proliferation, multifunctionality, rapid

Influence of Self-MHC Class I Recognition on the Dynamics of NK Cell Responses to Cytomegalovirus Infection.

Marc Potempa et al.

Journal of immunology (Baltimore, Md. : 1950), 208(7), 1742-1754 (2022-03-25)

Although interactions between inhibitory Ly49 receptors and their self-MHC class I ligands in C57BL/6 mice are known to limit NK cell proliferation during mouse CMV (MCMV) infection, we created a 36-marker mass cytometry (CyTOF) panel to investigate how these inhibitory

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Milli-Mark® 抗-FcεRI抗体，γ 亚基-FITC

Milli-Mark®, from rabbit