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product name
大鼠/小鼠生长激素ELISA, This Rat/Mouse Growth Hormone ELISA is used to measure & quantify Growth Hormone levels in Metabolism & Endocrine & Cell Signaling research.
质量水平
种属反应性
rat, mouse
包装
kit of 1 × 96 wells
参数
10 μL sample volume (4hr assay)
assay range
accuracy: 96-101%
linearity: 97-118%
sensitivity: 0.07 ng/mL
(10 μl sample size)
standard curve range: 0.07-50 ng/mL
技术
ELISA: suitable
输入
sample type serum
sample type cell culture supernatant
sample type plasma (K2 EDTA)
应用
research use
检测方法
colorimetric (450nm/590nm)
运输
wet ice
储存温度
2-8°C
一般描述
生长激素（GH）是一种23 kDa的循环垂体激素，大鼠GH在其GH序列中与小鼠GH具有约97%的同源性，与人蛋白具有约65%的同源性。生长激素的主要作用对象为中枢神经系统。在动物模型中，该激素针对神经退化性刺激产生神经保护作用，并防止缺氧缺血性脑损伤的神经损失。因此，随老化而出现的生长激素水平下降影响大脑功能，并导致记忆和认知损害。该大鼠/小鼠生长激素ELISA用于在代谢&内分泌&细胞信号转导研究中测量&定量生长激素水平。
应用
大鼠/小鼠生长激素ELISA已被用于测量或量化小鼠血液样品、异种移植物模型和血浆样品中的生长激素水平。
其他说明
室温3.5小时，10 μl血清、血浆或组织培养基
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
Iñigo Azcoitia et al.
Neurobiology of aging, 26(5), 697-703 (2005-02-15)
Decline of growth hormone (GH) with aging is associated to memory and cognitive alterations. In this study, the number of neurons in the hilus of the dentate gyrus has been assessed in male and female Wistar rats at 3, 6
Andre Sarmento-Cabral et al.
The Journal of endocrinology, 248(1), 31-44 (2020-10-29)
A reduction in hepatocyte growth hormone (GH)-signaling promotes non-alcoholic fatty liver disease (NAFLD). However, debate remains as to the relative contribution of the direct effects of GH on hepatocyte function vs indirect effects, via alterations in insulin-like growth factor 1
Reproductive dysfunction and decreased gnRH neurogenesis in a Mouse Model of cHARGE syndrome.
Layman WS, Hurd EA, Martin DM
Human Molecular Genetics null
Naomi Morozumi et al.
Peptides, 32(5), 1001-1007 (2011-02-05)
Ghrelin is an endogenous ligand for growth hormone secretagogue receptor 1a (GHS-R1a), and consists of 28 amino acid residues with octanoyl modification at Ser(3). The previous studies have revealed that N-terminal part of ghrelin including modified Ser(3) is the active
Supriya Sen et al.
Nature communications, 4, 1336-1336 (2013-01-10)
SR family RNA binding proteins regulate splicing of nascent RNAs in vitro but their physiological role in vivo is largely unexplored, as genetic deletion of many SR protein genes results in embryonic lethality. Here we show that SRSF3HKO mice carrying
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