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product name
人GIP(总)ELISA, This Human GIP (total) ELISA is used to measure & quantify GIP levels in Metabolism & Endocrine research.
质量水平
种属反应性
human
包装
kit of 1 × 96 wells
参数
20 μL sample volume (4hr assay)
assay range
accuracy: 86.7%
linearity: 99.9%
sensitivity: 8.2 pg/mL
standard curve range: 8.2-2000 pg/mL
技术
ELISA: suitable
输入
sample type cell culture supernatant
sample type serum
sample type plasma (K2 EDTA)
NCBI登记号
UniProt登记号
应用
research use
检测方法
colorimetric (450nm/590nm)
运输
wet ice
储存温度
2-8°C
基因信息
human ... GNAI2(2771)
一般描述
GIP也称抑胃肽或葡萄糖依赖性促胰岛素多肽,由位于人染色体17q12-q21的基因编码。它是由K 细胞在肠上皮中合成和分泌。胃肠道的GIP 分泌在葡萄糖糖稳态中起重要作用。 它在口服摄入营养素后刺激胰腺β细胞分泌胰岛素。此外,GIP 也促进胰岛素的生物合成和β-细胞增殖,并减缓β-细胞凋亡。GIP还通过刺激脂肪细胞中甘油三酯合成促进脂肪代谢。 GIP水平上升可导致肥胖和高胰岛素血症。该人GIP(总计)ELISA用于测量 & 定量代谢 & 内分泌研究中的GIP水平。
应用
人GIP(总)ELISA已用于测定血样中的总葡萄糖依赖性促胰岛素多肽(GIP)。
其他说明
研究亚类 肥胖 代谢疾病 室温,3.5 小时,,20 µL 样品体积,血清,血浆或组织培养基 研究类别 代谢
免责声明
仅供研究使用。不用于诊断操作。
警示用语:
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Met. Corr. 1 - Skin Sens. 1
WGK
WGK 3
Genomics, 17(3), 618-623 (1993-09-01)
To facilitate the positional cloning of the breast-ovarian cancer gene BRCA1, we constructed a high-density genetic map of the 8.3-cM interval between D17S250 and GIP on chromosome 17q12-q21. Markers were mapped by linkage in the CEPH and in extended kindreds
Dietary sugars stimulate fatty acid synthesis in adults.
The Journal of Nutrition null
Colesevelam improves oral but not intravenous glucose tolerance by a mechanism independent of insulin sensitivity and ?-cell function.
Diabetes Care null
Molecular metabolism, 6(2), 226-231 (2017-02-10)
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) possess multiple bioactive isoforms that are rendered non-insulinotropic by the enzyme dipeptidyl peptidase-4 (DPP-4). Recently, some ELISA kits have been developed to specifically measure "active" GIP and GLP-1, but it is unclear
American journal of physiology. Endocrinology and metabolism, 295(2), E350-E355 (2008-05-29)
Menopause and premature gonadal steroid deficiency are associated with increases in fat mass and body weight. Ovariectomized (OVX) mice also show reduced locomotor activity. Glucose-dependent-insulinotropic-polypeptide (GIP) is known to play an important role both in fat metabolism and locomotor activity.
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