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产品名称
人GIP（总）ELISA, This Human GIP (total) ELISA is used to measure & quantify GIP levels in Metabolism & Endocrine research.
质量水平
种属反应性
human
包装
kit of 1 × 96 wells
参数
20 μL sample volume (4hr assay)
assay range
accuracy: 86.7%
linearity: 99.9%
sensitivity: 8.2 pg/mL
standard curve range: 8.2-2000 pg/mL
技术
ELISA: suitable
输入
sample type cell culture supernatant
sample type serum
sample type plasma (K2 EDTA)
NCBI登记号
UniProt登记号
应用
research use
检测方法
colorimetric (450nm/590nm)
运输
wet ice
储存温度
2-8°C
基因信息
human ... GNAI2(2771)
一般描述
GIP也称抑胃肽或葡萄糖依赖性促胰岛素多肽，由位于人染色体17q12-q21的基因编码。它是由K 细胞在肠上皮中合成和分泌。胃肠道的GIP 分泌在葡萄糖糖稳态中起重要作用。 它在口服摄入营养素后刺激胰腺β细胞分泌胰岛素。此外，GIP 也促进胰岛素的生物合成和β-细胞增殖，并减缓β-细胞凋亡。GIP还通过刺激脂肪细胞中甘油三酯合成促进脂肪代谢。 GIP水平上升可导致肥胖和高胰岛素血症。该人GIP（总计）ELISA用于测量 & 定量代谢 & 内分泌研究中的GIP水平。
应用
人GIP（总）ELISA已用于测定血样中的总葡萄糖依赖性促胰岛素多肽（GIP）。
其他说明
研究亚类 肥胖 代谢疾病 室温，3.5 小时，,20 µL 样品体积，血清，血浆或组织培养基 研究类别 代谢
免责声明
仅供研究使用。不用于诊断操作。
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Met. Corr. 1 - Skin Sens. 1
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
L A Anderson et al.
Genomics, 17(3), 618-623 (1993-09-01)
To facilitate the positional cloning of the breast-ovarian cancer gene BRCA1, we constructed a high-density genetic map of the 8.3-cM interval between D17S250 and GIP on chromosome 17q12-q21. Markers were mapped by linkage in the CEPH and in extended kindreds
Tsuyoshi Yanagimachi et al.
Molecular metabolism, 6(2), 226-231 (2017-02-10)
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) possess multiple bioactive isoforms that are rendered non-insulinotropic by the enzyme dipeptidyl peptidase-4 (DPP-4). Recently, some ELISA kits have been developed to specifically measure "active" GIP and GLP-1, but it is unclear
Dietary sugars stimulate fatty acid synthesis in adults.
Elizabeth J Parks, Lauren E Skokan, Maureen T Timlin, Carlus S Dingfelder
The Journal of Nutrition null
Colesevelam improves oral but not intravenous glucose tolerance by a mechanism independent of insulin sensitivity and ?-cell function.
Anna L Marina,Kristina M Utzschneider,Lorena A Wright,Brenda K Montgomery et al.
Diabetes Care null
Frank Isken et al.
American journal of physiology. Endocrinology and metabolism, 295(2), E350-E355 (2008-05-29)
Menopause and premature gonadal steroid deficiency are associated with increases in fat mass and body weight. Ovariectomized (OVX) mice also show reduced locomotor activity. Glucose-dependent-insulinotropic-polypeptide (GIP) is known to play an important role both in fat metabolism and locomotor activity.
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