推荐产品
一般描述
Antipain is known for regulating the number of chromosomal aberrations caused by the S-phase-dependent alkylating agent N-methyl-N′-nitro-N-nitrosoguanidine. It can also diminish the nuclear binding of the estrogen-receptor complex in MCF-7 breast tumor cells.
应用
Antipain has been used in microfluidic chip assay.
生化/生理作用
Inhibitor Type: Protease Inhibitors
质量
pH 1% aqueous solution: 5.2
外形
Lyophilized no preservatives.
Properties: Soluble in H2O, methanol and DMSO (Stock solution: 10 mM). Stable at -20° C.
Mechanism of action: Formation of a hemicetal adduct between the aldehyde group of the inhibitor and the active serine of the proteinase.
Inhibition spectrum: Inhibits papain, trypsin and plasmin to a lesser extent. More specific for papain and trypsin than leupeptin. The inhibitory potency of antipain is 100-fold higher than that of elastatinal.
Pale yellow powder; material is isolated from cultured media of microorganisms. As with many of these compounds, they are too inherently unstable to allow for high standards of purity. The homogeneity of these compounds cannot be guaranteed except for their specific inhibitory activities.
Properties: Soluble in H2O, methanol and DMSO (Stock solution: 10 mM). Stable at -20° C.
Mechanism of action: Formation of a hemicetal adduct between the aldehyde group of the inhibitor and the active serine of the proteinase.
Inhibition spectrum: Inhibits papain, trypsin and plasmin to a lesser extent. More specific for papain and trypsin than leupeptin. The inhibitory potency of antipain is 100-fold higher than that of elastatinal.
Pale yellow powder; material is isolated from cultured media of microorganisms. As with many of these compounds, they are too inherently unstable to allow for high standards of purity. The homogeneity of these compounds cannot be guaranteed except for their specific inhibitory activities.
储存及稳定性
Maintain dry at -20ºC for up to 18 months. Store reconstituted product in aliquots at -20ºC for up to 9 months. Do not thaw and refreeze.
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Antipain-mediated suppression of X-ray-induced chromosomal aberrations in human lymphocytes
Afzal, et al.
Carcinogenesis, 10(7), 1193-1196 (1989)
Tumor-associated macrophage-derived exosomal miR21-5p promotes tumor angiogenesis by regulating YAP1/HIF-1alpha axis in head and neck squamous cell carcinoma
Yan Q, et al.
Cellular and Molecular Life Sciences, 81(1), 1-23 (2024)
Protease inhibitor antipain reduces nuclear binding of estrogen-receptor complex in MCF-7 breast tumor cells
Umans RS, et al.
Carcinogenesis, 5(10), 1355-1357 (1984)
Structure of antipain, a new Sakaguchi-positive product of streptomyces.
S Umezawa et al.
The Journal of antibiotics, 25(4), 267-270 (1972-04-01)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门