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一般描述
二肽基肽酶IV（DPP IV）是一种二聚II型膜内在糖蛋白，属于脯氨酰特异性蛋白酶家族的成员。它在上皮组织和非上皮组织中大量表达。它在肾脏和结肠中高度表达。
应用
研究类别
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生化/生理作用
二肽基肽酶IV（DPP IV）可控制胰岛素刺激激素、胰高血糖素样肽（GLP-1）以及葡萄糖依赖性促胰岛素多肽（GIP）等。它作为治疗II型糖尿病（T2DM）的治疗靶点前景可观。′除了催化作用之外，DPP-4还可用作结合蛋白和细胞外蛋白因子的配体。DPP-4抑制使GLP-1和GIP的活性延长，因此，DPP-4抑制剂有助于维持葡萄糖的稳态。与早期口服降血糖药物相比，DPP IV抑制剂可延长血糖控制的时间。
储存及稳定性
收到后，存放在4°C。如果需要长期储存超过2周，建议储存在–20°C。
Sebastiano Bruno Solerte et al.
Acta diabetologica, 57(7), 779-783 (2020-06-09)
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Rajesh Gupta et al.
Current drug targets, 10(1), 71-87 (2009-01-20)
Dipeptidyl peptidase IV (DPP IV) is a key regulator of insulin-stimulating hormones, glucagon-like peptide (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), thus it is a promising target for the treatment of Type 2 Diabetes mellitus (T2DM). Inhibition of plasma DPP IV
Sourav De et al.
Mini reviews in medicinal chemistry, 19(2), 88-97 (2018-04-26)
Diabetes mellitus is an emerging predator and affecting around 422 million adults worldwide. Higher levels of circulating insulin and increased pressure on the pancreas to produce insulin have been inferred as possible etiology for diabetes leading to a higher risk
Lucienne Juillerat-Jeanneret
Journal of medicinal chemistry, 57(6), 2197-2212 (2013-10-09)
The proline-specific dipeptidyl aminopeptidase IV (DPP IV, DPP-4, CD26), widely expressed in mammalians, releases X-Pro/Ala dipeptides from the N-terminus of peptides. DPP IV is responsible of the degradation of the incretin peptide hormones regulating blood glucose levels. Several families of
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