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CKT1MAG-97K

MILLIPLEX^® Canine Kidney Toxicity Expanded Magnetic Bead Panel 1, CKT1MAG-97K

Name: MILLIPLEX<SUP>®</SUP> Canine Kidney Toxicity Expanded Magnetic Bead Panel 1, CKT1MAG-97K
Brand: MM

The analytes available for this multiplex kit are: Clusterin, Cystatin C, Kidney Injury Molecule-1 (KIM-1), IL-8, Lipocalin-2/NGAL, MCP-1, Osteopontin (OPN).

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UNSPSC代码:

12161503

eCl@ss:

32161000

NACRES:

NA.84

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质量水平

200

种属反应性

canine

制造商/商品名称

Milliplex^®

assay range

accuracy: 89-107%
sensitivity: 0.005-0.630 ng/mL
(All other analytes; MinDC +2SD)
sensitivity: 0.670 pg/mL
(KIM-1; MinDC +2SD)
standard curve range: 0.01-10 ng/mL
(Cystatin C)
standard curve range: 0.01-10 ng/mL
(Osteopontin)
standard curve range: 0.03-20 ng/mL
(Lipocalin-2/NGAL)
standard curve range: 0.07-50 ng/mL
(IL-8)
standard curve range: 0.07-50 ng/mL
(MCP-1)
standard curve range: 1.0-700 pg/mL
(KIM-1)
standard curve range: 1.4-1,000 ng/mL
(Clusterin)

技术

multiplexing: suitable

检测方法

fluorometric (Luminex xMAP)

运输

wet ice

一般描述

As one of the leading causes of drug candidate attrition, toxicity research is receiving more attention, especially in the search of sensitive, organ-specific toxicity biomarkers. In pharmaceutical and chemical industries, the kidney is routinely assessed during toxicity evaluations. The importance of the kidney as a central detoxification organ leads to a high exposure of renal tissue to drugs, reactive metabolites, and environmental compounds. Traditional markers for assessing renal toxicity, such as blood urea nitrogen (BUN) and serum creatinine, are insensitive and non-specific. For improved, non-invasive detection of acute nephrotoxicity, a panel of novel urinary kidney biomarkers has been identified and verified for preclinical studies in relevant animal species. The MILLIPLEX^® portfolio provides a valuable research assay to investigate multiple biomarkers of kidney injury in canine urine samples using the Luminex^® xMAP^® instrument platform.

The MILLIPLEX^® Canine Kidney Toxicity Expanded Panel 1 is to be used for the simultaneous quantification of the following 7 analytes in any combination in canine urine samples: Clusterin, Cystatin C, Kidney Injury Molecule-1 (KIM-1), IL-8, Lipocalin-2/NGAL, MCP-1, and Osteopontin (OPN). This kit uses a 96-well format, contains a lyophilized standard cocktail, two internal assay quality controls while can measure up to 38 samples in duplicate.

The Luminex^® xMAP^® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.

Panel Type: Toxicity

应用

Analytes: Clusterin, Cystatin C, Kidney Injury Molecule-1 (KIM-1), IL-8, Lipocalin-2/NGAL, MCP-1, Osteopontin (OPN)
Recommended Sample Type: Canine urine
Recommended Sample Dilution: 25 μL of 1:2 diluted urine for normal subjects; optimal dilutions for disease subjects should be determined
Assay Run Time: Primary incubation of 2 hours, followed by a secondary incubation of 1 hour, both at room temperature (20-25°C)
Research Category: Toxicology

特点和优势

Design your multiplex kit by choosing available analytes within this panel.

其他说明

Please contact Technical Service for linearity of dilution.

Sensitivity: See kit protocol for individual analytes sensitivities.

法律信息

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

象形图

GHS06,GHS08,GHS05,GHS09

警示用语：

Danger

危险声明

H302 + H332,H311,H317,H318,H373,H411

预防措施声明

P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P314

危险分类

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

靶器官

Respiratory Tract

WGK

WGK 3

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Monitoring of serum and urinary biomarkers during treatment of canine visceral leishmaniasis.

Alvaro Felipe de Lima Ruy Dias et al.

Veterinary world, 13(8), 1620-1626 (2020-10-17)

Canine visceral leishmaniasis (CanL) has a broad spectrum of changes, with kidney disease being considered the main cause of mortality. Thus, this study aimed to monitor serum and urinary biomarkers in response to two short-term treatments for CanL. Thirty dogs

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MILLIPLEX^® Canine Kidney Toxicity Expanded Magnetic Bead Panel 1, CKT1MAG-97K

The analytes available for this multiplex kit are: Clusterin, Cystatin C, Kidney Injury Molecule-1 (KIM-1), IL-8, Lipocalin-2/NGAL, MCP-1, Osteopontin (OPN).

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