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生物来源
mouse
质量水平
抗体形式
purified immunoglobulin
克隆
HD37, monoclonal
种属反应性
human
制造商/商品名称
Chemicon®
技术
flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
同位素/亚型
IgG1
NCBI登记号
UniProt登记号
运输
wet ice
基因信息
human ... CD19(930)
特异性
The CD19 antigen (90 kDa) is expressed from the earliest stages of B-progenitor development, on all peripheral B cells including germinal centre B cells and all B cell lines and B cell leukaemias tested. T cell and monocytic cell lines are negative and the antigen is lost on B cell maturations to plasma cells. The antigen is a type I integral membrane glycoprotein whose in vitro inhibition will influence B cell activation and proliferation.
应用
Anti-CD19 Antibody, clone HD37 detects level of CD19 & has been published & validated for use in FC, IP, IH.
Identification of CD19 positive B lymphocytes and malignant B cells by indirect immunofluorescence staining
Leukaemia and lymphoma phenotyping
Identification of normal and malignant CD19 positive B lymphocytes in cryostat frozen sections
Immunoprecipitation of the CD19 antigen
Studies of the CD19/21 complex in B cell activation and the control of B cell development
Optimal working dilutions must be determined by the end user.
Leukaemia and lymphoma phenotyping
Identification of normal and malignant CD19 positive B lymphocytes in cryostat frozen sections
Immunoprecipitation of the CD19 antigen
Studies of the CD19/21 complex in B cell activation and the control of B cell development
Optimal working dilutions must be determined by the end user.
Research Category
Inflammation & Immunology
Inflammation & Immunology
Research Sub Category
Immunoglobulins & Immunology
Immunoglobulins & Immunology
联系
Replaces: CBL1322
外形
Format: Purified
The monoclonal is presented at a concentration of 100μg/1ml in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application.
储存及稳定性
For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Maristella Maggi et al.
Cancers, 13(22) (2021-11-28)
E. coli L-asparaginase is an amidohydrolase (EC 3.5.1.1) which has been successfully used for the treatment of Acute Lymphoblastic Leukemia for over 50 years. Despite its efficacy, its side effects, and especially its intrinsic immunogenicity, hamper its usage in a
G F Fischer et al.
Journal of immunology (Baltimore, Md. : 1950), 144(2), 638-641 (1990-01-15)
The CD24 Ag is present on human B cells from the earliest stages of B lineage development and is lost on terminal B cell maturation to plasma cells. This Ag is also expressed on mature forms of granulocytes. We studied
Sylvia Eash et al.
The American journal of pathology, 164(2), 419-428 (2004-01-27)
JC virus (JCV), a member of the polyomavirus family, causes a demyelinating disease of the central nervous system (CNS) in humans known as progressive multifocal leukoencephalopathy. Although glial cells are the principal target of JCV productive infection in progressive multifocal
Gladys S Ingle et al.
British journal of haematology, 140(1), 46-58 (2007-11-10)
CD19 and CD21 (CR2) are co-receptors found on B-cells and various B-cell lymphomas, including non-Hodgkin lymphoma. To evaluate their suitability as targets for therapy of such lymphomas using internalization-dependent antibody-drug conjugates [such as antibody-4-(N-maleimidomethyl)cyclohexane-1-carboxylate, (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine) (MCC-DM1) conjugates, which require lysosomal
A Greiner et al.
Developmental immunology, 6(3-4), 187-195 (1998-11-14)
Low-grade MALT-type lymphomas are malignancies of mucosal marginal-zone B cells and preceded by reactive inflammatory lymphoid tissue. Experimental observations suggest that antigen and CD40 Ligand act during cognate T/B cell interaction and are crucial for germinal center B-cell maturation generating
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