推荐产品
生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
mouse, human, rat
制造商/商品名称
Chemicon®
技术
immunoprecipitation (IP): suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... SLC2A4(6517)
特异性
对来自肌肉和脂肪组织的人葡萄糖转运蛋白-4具有特异性。 该抗血清不与GLUT-1发生交叉反应。 血清沉淀的葡萄糖转运蛋白的分子量约为46 kDa。
免疫原
部分纯化GLUT-4
应用
研究子类别
胰岛素/能量信号
胰岛素/能量信号
研究类别
信号传导
信号传导
脂肪和肌肉组织中GLUT-4活性的蛋白质印迹分析（5μg/ml）
GLUT-4的免疫沉淀（5μg/ml）
最佳工作稀释度必须由最终用户确定。
GLUT-4的免疫沉淀（5μg/ml）
最佳工作稀释度必须由最终用户确定。
该抗葡萄糖转运蛋白GLUT-4抗体经验证可用于IP、WB中葡萄糖转运蛋白GLUT-4的检测。
目标描述
46kda
外形
免疫亲和纯化
纯化免疫球蛋白，溶于含0.01% 叠氮化钠的PBS中。
储存及稳定性
若购买后1个月内使用，则储存于+4°C，若要长期储存，则将抗体等分成小体积并储存于-20°C。
分析说明
对照
阳性对照：3T3 L1脂肪细胞膜
阳性对照：3T3 L1脂肪细胞膜
其他说明
浓度：请参考批次特异性浓缩物的检验报告。
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Haiyan Wang et al.
Journal of applied physiology (Bethesda, Md. : 1985), 132(1), 140-153 (2021-12-10)
Previous studies demonstrated that acute exercise can enhance glucose uptake (GU), γ3-AMP-activated protein kinase (AMPK) activity, and Akt substrate of 160 kDa (AS160) phosphorylation in skeletal muscles from low-fat diet (LFD)- and high-fat diet (HFD)-fed male rats. Because little is
Haiyan Wang et al.
Facets (Ottawa), 7, 774-791 (2022-11-17)
Attenuated skeletal muscle glucose uptake (GU) has been observed with advancing age. It is important to elucidate the mechanisms linked to interventions that oppose this detrimental outcome. Earlier research using young rodents and (or) cultured myocytes reported that treatment with
Exercise restores insulin, but not adiponectin, response in skeletal muscle of high-fat fed rodents.
Roberto A Gulli et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 303(10), R1062-R1070 (2012-10-12)
High-fat (HF) diets impair skeletal muscle response to the insulin-sensitizing adipokine adiponectin (Ad) in rodents, preceding the development of insulin resistance. Skeletal muscle insulin response in HF-fed rats can be restored with chronic exercise; whether recovery of skeletal muscle Ad
Naveen Sharma et al.
Biochimica et biophysica acta, 1822(11), 1735-1740 (2012-08-01)
Calorie restriction (CR; ~60% of ad libitum, AL, consumption) improves insulin-stimulated glucose uptake in skeletal muscle. The precise cellular mechanism for this healthful outcome is unknown, but it is accompanied by enhanced insulin-stimulated activation of Akt. Previous research using Akt2-null
Xiaohua Zheng et al.
PloS one, 15(2), e0223340-e0223340 (2020-02-14)
The Rab GTPase activating protein known as Akt substrate of 160 kDa (AS160 or TBC1D4) regulates insulin-stimulated glucose uptake in skeletal muscle, the heart, and white adipose tissue (WAT). A novel rat AS160-knockout (AS160-KO) was created with CRISPR/Cas9 technology. Because
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