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CBL1512

抗整合素 αM [CD11b] 抗体，克隆OX-42

Name: 抗整合素 αM [CD11b] 抗体，克隆OX-42
Brand: MM

clone OX-42, Chemicon^®, from mouse

别名:

CD11b

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关于此项目

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

OX-42, monoclonal

Application:

FACS, IHC (p), IP

Citations:

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属性

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

OX-42, monoclonal

species reactivity

rat

packaging

antibody small pack of 25 μg

manufacturer/tradename

Chemicon^®

technique(s)

flow cytometry: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, immunoprecipitation (IP): suitable

isotype

IgG2a

NCBI accession no.

NM_000632.3

UniProt accession no.

P11215

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

rat ... Itgam(25021)

说明

General description

整联蛋白αM/β2与单核细胞、巨噬细胞和粒细胞的各种粘附性各种相互作用以及介导补体包被颗粒的摄取有关。它与第三补体成分iC3b片段的受体CR 3相同。它可能识别C3b中的R-G-D肽。整合素αM/β2也是纤维蛋白原，因子X和ICAM1的受体。可识别纤维蛋白原γ链的P1和P2肽。

Immunogen

大鼠腹腔巨噬细胞

Application

使用经验证可用于FC、IH、IH（P）&IP的抗整合素αM CD11b抗体（克隆OX-42）检测整合素αM[CD11b]。

研究子类别
整合素

研究类别
细胞结构

Biochem/physiol Actions

可识别大多数巨噬细胞（包括常驻腹膜和活化巨噬细胞）、枯否细胞，但仅识别约35%的肺泡巨噬细胞。该抗体还广泛标记大脑中的树突状细胞，粒细胞和具有小胶质细胞形态的细胞。该抗体沉淀150、103和95 kDa的三种多肽。该抗体可抑制补体介导的玫瑰花结，可能是IC3b的人类受体的大鼠等效物（称为CR3）。
融合伴侣：NSO骨髓瘤细胞系。

Physical form

单克隆抗体存在于含有10mM叠氮化钠的磷酸盐缓冲液中。

形式：纯化

纯化的蛋白 A

Preparation Note

若购买后1个月内使用，则储存于+4°C，若要长期储存，则将抗体等分成小体积并储存于-20°C。

Analysis Note

对照
脑组织

Other Notes

浓度：请参考批次特异性浓缩物的检验报告。

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

存储类别

12 - Non Combustible Liquids

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Reduction of ?-amyloid deposits by ?-secretase inhibitor is associated with the attenuation of secondary damage in the ipsilateral thalamus and sensory functional improvement after focal cortical infarction in hypertensive rats.

Zhang, Y; Xing, S; Zhang, J; Li, J; Li, C; Pei, Z; Zeng, J

Journal of Cerebral Blood Flow and Metabolism null

Changes in interleukin-1 signal modulators induced by 3,4-methylenedioxymethamphetamine (MDMA): regulation by CB2 receptors and implications for neurotoxicity.

Elisa Torres et al.

Journal of neuroinflammation, 8, 53-53 (2011-05-21)

3,4-Methylenedioxymethamphetamine (MDMA) produces a neuroinflammatory reaction in rat brain characterized by an increase in interleukin-1 beta (IL-1β) and microglial activation. The CB2 receptor agonist JWH-015 reduces both these changes and partially protects against MDMA-induced neurotoxicity. We have examined MDMA-induced changes

HDAC inhibitor increases histone H3 acetylation and reduces microglia inflammatory response following traumatic brain injury in rats.

Zhang, B; West, EJ; Van, KC; Gurkoff, GG; Zhou, J; Zhang, XM; Kozikowski, AP; Lyeth, BG

Brain Research null

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全球贸易项目编号

货号	GTIN
CBL1512-25UG	04054839342820