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Merck
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AP1140

Sigma-Aldrich

Anti-GBA Mouse mAb (2E2)

liquid, clone 2E2, Calbiochem®

别名:

Anti-Glucosidase β, Acid

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

mouse

质量水平

抗体形式

purified antibody

抗体产品类型

primary antibodies

克隆

2E2, monoclonal

形式

liquid

不包含

preservative

种属反应性

human

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
avoid repeated freeze/thaw cycles

同位素/亚型

IgG2a

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... GBA(2629)

一般描述

Anti-GBA, mouse monoclonal, clone 2E2, recognizes the ~60 kDa GBA in MCF-7 and HeLa cells and human breast cancer tissue. It is validated for use in ELISA, WB, ICC, and IHC on paraffin sections.
Purified mouse monoclonal antibody. Recognizes the ~60 kDa GBA protein.
Recognizes the ~60 kDa GBA protein in MCF-7 and HeLa cells and human breast cancer tissue.

免疫原

A recombinant polypeptide corresponding to amino acids of 146-236 human GBA, expressed as a GST fusion protein

警告

Toxicity: Regulatory Review (Z)

分析说明

Negative Control
293T
Positive Control
MCF-7 cells, HeLa cells, Human breast cancer tissue

其他说明

Campeau, P.M., et al. 2009. Blood114, 3181.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Laura J Smith et al.
Human molecular genetics, 32(5), 773-789 (2022-09-22)
Sequence variants or mutations in the GBA gene are numerically the most important risk factor for Parkinson disease (PD). The GBA gene encodes for the lysosomal hydrolase enzyme, glucocerebrosidase (GCase). GBA mutations often reduce GCase activity and lead to the
Ruggero Ferrazza et al.
Biochemical and biophysical research communications, 478(3), 1141-1146 (2016-08-20)
Mutations in LRRK2 gene cause inherited Parkinson's disease (PD) and variations around LRRK2 act as risk factor for disease. Similar to sporadic disease, LRRK2-linked cases show late onset and, typically, the presence of proteinaceous inclusions named Lewy bodies (LBs) in

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