β-Amyloid Peptide

Beta Amyloid (1-43), ultra pure, TFA

MOL. WT.: 4615.5 Da by Mass Spec Analysis (theoretical 4615.2)

Different researchers claim enhanced activity due to different salts.



The TFA salt is what has been the industry standard.



The HFIP makes the beta-amyloid homogenously monomeric.



The NaOH apparently make it monomeric too and is also water soluble, which the TFA salt and HFIP are not.



The HCl salt is supposed to be more biological, as TFA is not found in the body.



By offering the different salts, it lets the researchers duplicate the different assays that have been developed by other researchers (see below).



TFA: Shu-chuan Jao, S-C, et. al. 1997, Amyloid; Int J Exp. Clinical Invest. 4, 231

HFIP: Stine, W.B. et. al. 2003, J. Biol. Chem, 278, 11612

NaOH: Fezoui, Y., et. al. 2000, Amyloid, 7, 166

HCL: Kanek, I and Tutumi, S., 1997, J. Neurochem, 68, 438

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-Thr

White lyophilized powder. Resuspend in 1% NH4OH at a concentration of 1 mg/mL. Sonicate for 30 seconds to 1 minute after it has gone into solution. To bring into your solution: After resuspension, add 5x or 10x buffer stock (PBS, TBS) and water to bring t

Maintain lyophilized material at -20ºC for up to 12 months after date of receipt. After reconstitution maintain at -20ºC to -70ºC for up to 2 weeks in undiluted aliquots. Avoid freeze/thaw cycles to avoid aggregation.

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