突触核蛋白，α，重组人

Research area: Neuroscience

α-Synuclein, a member of the synuclein family of proteins that localize to presynaptic terminals under physiological conditions. It is comprised of three primary regions: an amino terminus containing apolipoprotein lipid-binding motifs, which are anticipated to form amphiphilic helices. The central region, known as non-Aβ component (NAC) containing a hydrophobic domain that gives β-sheet potential, and the carboxyl terminus, characterized by a high negative charge and remains unstructured. Under physiological conditions, members of the synuclein family, including α-synuclein, are predominantly neuronal proteins.

Synuclein, α, recombinant human has been used:

• for preparation of α-synuclein fibrils to access the SAR228810 antibody against the risk of amyloid-related imaging abnormalities (ARIA).
• to study the formation of isoasparate protein damage responsible to trigger familial Parkionsonian phenotypes.
• to study its interaction with iron and copper, in order to understand their role in proteinopathies.

Synuclein, α is the principal component of Lewy bodies and a pathological hallmark of synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). The deposition of αS aggregates is a defining characteristic of all these diseases.

从TBS中冻干。以1mg/mL的浓度重悬于水中。

在接收之日起，将冻干物料在-20ºC下保存长达12个月。复溶后，以未稀释的等分试样在-20ºC至-70ºC下保存长达2周。避免冻融循环，以避免聚集。

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