推荐产品
生物来源
human
质量水平
100
300
方案
>98% (SDS-PAGE)
表单
liquid
制造商/商品名称
Chemicon®
浓度
3.5 mg/mL
NCBI登记号
UniProt登记号
一般描述
C反应蛋白(CRP)是一种同源五聚体急性期炎性蛋白,属于正五聚蛋白家族。它是一种高度保守的血浆蛋白,主要在肝细胞中产生。它也由淋巴细胞、平滑肌细胞、巨噬细胞、内皮细胞和脂肪细胞合成。
应用
C反应蛋白(CRP)已用于:
- 作为模型分析物,使用非竞争夹心免疫分析法联合表面等离子体场增强荧光光谱法(SPFS)进行血清中CRP的抗干扰检测
- 确定收集胎盘1 (CL-P1)参与CRP介导的补体激活,并研究这种补体激活的下游效应
- 通过与CRP相互作用形成炎症致病性反应,研究凝集素样氧化低密度脂蛋白受体1 (LOX-1)对CRP诱导的补体活化的作用
生化/生理作用
C反应蛋白(CRP)在补体途径、细胞凋亡、吞噬作用、一氧化氮(NO)释放等过程中起着至关重要的作用。它还可调节白细胞介素-6和肿瘤坏死因子-α的产生。患有阑尾炎、胆囊炎、胰腺炎和脑膜炎的患者CRP水平升高。CRP可促进巨噬细胞中低密度脂蛋白的摄取。由于在心血管疾病的病理生理中起着至关重要的作用,使它成为炎症和心血管事件的有用标志物。
质量
当针对抗全人血清以2 mg/mL进行检验时,无沉淀条带。
外形
液体溶于100mM NaCl、10mM Tris-HCl和0.1%叠氮化钠、2mM CaCl2
储存及稳定性
在2-8°C的无菌条件下保持长达一年。请勿冷冻。在处理任何潜在感染性体液时,应采取全面的安全预防措施。
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Lectin-like Oxidized LDL Receptor 1 Is Involved in CRP-Mediated Complement Activation.
Clinical Chemistry null
Development of a cluster of differentiation antibody-based protein microarray.
Journal of Immunological Methods null
Biochimica et biophysica acta, 1860(6), 1118-1128 (2016-03-01)
C-reactive protein (CRP) is a plasma pentraxin family protein that is massively induced as part of the innate immune response to infection and tissue injury. CRP and other pentraxin proteins can activate a complement pathway through C1q, collectins, or on
Pharmaceutics, 14(6) (2022-06-25)
Gut modulation by multi-strain probiotics (MSPs) is considered an effective strategy for treating inflammatory bowel disease (IBD). The combination of nanomaterial-based MSPs can improve their viability and resistance and can allow their targeted release in the gastrointestinal tract to be
Clinical chemistry, 56(3), 478-481 (2010-01-16)
C-reactive protein (CRP) increases in response to inflammation and is purported to be a risk factor for atherogenesis. We recently demonstrated that a scavenger receptor, lectin-like oxidized LDL receptor (LOX-1), is a receptor for CRP. In light of the overlapping
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