ABT79
抗-WASH 复合物亚基FAM21C抗体
from rabbit
别名:
family with sequence similarity 21, member C, vaccinia virus penetration factor, WASH complex subunit FAM21C
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunocytochemistry
western blot
western blot
Species reactivity:
mouse, human
Citations:
12
Technique(s):
immunocytochemistry: suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗-WASH 复合物亚基FAM21C抗体, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, human
technique(s)
immunocytochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... WASHC4(23325)
Analysis Note
对照
HEK293 细胞裂解液
HEK293 细胞裂解液
通过蛋白质印迹对HEK293细胞裂解物中的抗体进行了评估。
蛋白质印迹分析：5 µg/mL的该抗体在 10 µg HEK293 细胞裂解物中检测到 WASH复合物亚基FAM21C。
蛋白质印迹分析：5 µg/mL的该抗体在 10 µg HEK293 细胞裂解物中检测到 WASH复合物亚基FAM21C。
Application
免疫细胞化学分析：一个先前批次的1：500稀释液在NIH/3T3、A431和HeLa细胞中检测到WASH 复合物亚基FAM21C。
抗-WASH 复合物亚基FAM21C抗体可检测WASH 复合物亚基FAM21C的水平& 已有相关文献发表&经验证可用于IC & WB。
研究子类别
细胞骨架信号转导
细胞骨架信号转导
研究类别
细胞结构
细胞结构
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
FAM21C，也称WASH复合物亚基FAM21C，是500 kDa 核心复合物的一部分，该复合物使Wiskott-Aldrich综合征蛋白（WASH）能够发挥功能。FAM21C 存在于早期内吞体膜中。FAM21C与CAPZ协作，阻止其肌动蛋白加帽活性，连接WASH和内吞体，并且是逆运复合体介导的WASH依赖性分选所必需的。
观测值〜145 kDa
>200 kDa 和 ~10 kDa处可能观察到非特异性条带
>200 kDa 和 ~10 kDa处可能观察到非特异性条带
Immunogen
对应于人WASH复合物亚基FAM21C的重组蛋白。
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
形式：纯化
纯化的兔多克隆抗体，溶于含有0.1 M Tris-甘氨酸（pH 7.4）、150 mM NaCl和0.05％叠氮化钠的缓冲液中。
蛋白G纯化
Preparation Note
自收到之日起，在2-8°C条件下可稳定保存1年。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Matthew N J Seaman et al.
Journal of cell science, 131(12) (2018-05-20)
The retromer complex is a vital component of the endosomal protein sorting machinery necessary for sorting into both the endosome-to-Golgi retrieval pathway and also the endosome-to-cell-surface recycling pathway. Retromer mediates cargo selection through a trimeric complex comprising VPS35, VPS29 and
Yi Cui et al.
Traffic (Copenhagen, Denmark), 22(4), 123-136 (2020-12-22)
Retromer core complex is an endosomal scaffold that plays a critical role in orchestrating protein trafficking within the endosomal system. Here we characterized the effect of the Parkinson's disease-linked Vps35 D620N in the endo-lysosomal system using Vps35 D620N rescue cell
Jenai Quan et al.
mBio, 15(8), e0144524-e0144524 (2024-07-02)
Neurotropic alphaherpesviruses, including herpes simplex virus type 1 and pseudorabies virus, establish a lifelong presence within the peripheral nervous system of their mammalian hosts. Upon entering cells, two conserved tegument proteins, pUL36 and pUL37, traffic DNA-containing capsids to nuclei. These
Rakesh Kulkarni et al.
Life science alliance, 6(4) (2023-01-31)
FAM21 (family with sequence similarity 21) is a component of the Wiskott-Aldrich syndrome protein and SCAR homologue (WASH) protein complex that mediates actin polymerization at endosomal membranes to facilitate sorting of cargo-containing vesicles out of endosomes. To study the function
Heather E Miller et al.
PLoS pathogens, 14(4), e1007005-e1007005 (2018-04-19)
Coxiella burnetii is an intracellular bacterium that replicates within an expansive phagolysosome-like vacuole. Fusion between the Coxiella-containing vacuole (CCV) and late endosomes/multivesicular bodies requires Rab7, the HOPS tethering complex, and SNARE proteins, with actin also speculated to play a role.
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