推荐产品
生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
human
种属反应性（根据同源性预测）
porcine (based on 100% sequence homology), rat (based on 100% sequence homology), orangutan (Sumatran; based on 100% sequence homology), mouse (based on 100% sequence homology)
技术
dot blot: suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
phosphorylation (pTyr665)
基因信息
human ... PEAK1(79834)
一般描述
Pseudopodium-enriched atypical kinase 1 (Peak1; KIAA2002, or sgk269) is a ubiquitous non-receptor tyrosine kinase that belongs to the NFK3 family. It interacts with actin filaments via its N-terminal actin-targeting region. It also modulates the activity of multiple cytoskeletal regulatory proteins such as paxillin, p130Cas, Erk, and Crk; and mediates cell proliferation and migration via the Ras/Raf/Erk and Src-p130Cas-Crk-Paxillin pathways. Peak1 may play an important role in the progression of tumors.
特异性
This antibody recognizes Peak phosphorylated at Tyr665.
免疫原
Epitope: Phosphorylated Tyr665
KLH-conjugated linear peptide corresponding to human Peak phosphorylated at Tyr665.
应用
This phospho-Peak antibody is validated for use in WB & Dot Blot for the detection of the phospho-Peak protein.
Western Blot Analysis: A representative lot was used by an independent laboratory in 293T cells transfected with wildtype GFP-Peak. (Dr. Richard Klemke, University of California-San Diego.)
质量
Evaluated by Dot Blot in modified and non modified peptides of phosphorylated and non-phosphorlyated Peak proteins.
Dot Blot (Specificity) Analysis: A representative lot blocked phospho-Peak (Tyr665) in modified and non modified peptides of phosphorylated and non-phosphorlyated Peak proteins.
Dot Blot (Specificity) Analysis: A representative lot blocked phospho-Peak (Tyr665) in modified and non modified peptides of phosphorylated and non-phosphorlyated Peak proteins.
目标描述
220 kDa calculated
分析说明
Control
Modified and non modified peptides of phosphorylated and non-phosphorlyated Peak proteins
Modified and non modified peptides of phosphorylated and non-phosphorlyated Peak proteins
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Collagen signaling enhances tumor progression after anti-VEGF therapy in a murine model of pancreatic ductal adenocarcinoma.
Aguilera, KY; Rivera, LB; Hur, H; Carbon, JG; Toombs, JE; Goldstein, CD; Dellinger et al.
Cancer Research null
Kristina Y Aguilera et al.
Molecular cancer therapeutics, 16(11), 2473-2485 (2017-09-03)
The extracellular matrix (ECM), a principal component of pancreatic ductal adenocarcinoma (PDA), is rich in fibrillar collagens that facilitate tumor cell survival and chemoresistance. Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase that specifically binds fibrillar collagens and
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