产品名称
抗-LGN抗体, serum, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, rat
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Gpsm2(76123)
Analysis Note
对照
心脏组织裂解物
心脏组织裂解物
通过蛋白质印迹对大鼠 E16心脏组织裂解物进行了评估。
蛋白质印迹分析：该抗体的1：1,000稀释液在大鼠E16心脏组织裂解液中检测到LGN。
蛋白质印迹分析：该抗体的1：1,000稀释液在大鼠E16心脏组织裂解液中检测到LGN。
Application
抗-LGN 抗体是一种高度特异性的兔多克隆抗体，靶向LGN&已在蛋白质印迹中进行了检验。
研究子类别
细胞骨架
细胞骨架
研究类别
细胞结构
细胞结构
蛋白印迹分析：一个代表性批次的1：1,000稀释液在小鼠E16 脑组织裂解物中检测到LGN。
Biochem/physiol Actions
其他同源性：人（85%序列同源性）和鸡（75%序列同源性）。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
LGN也称G蛋白信号调节因子2（GPSM2）。LGN在细胞结构和纺锤体极定位（spindle pole orientation）中起重要作用。在成神经细胞分裂过程中，LGN 也稳定顶端复合物（apical complex）。由于染色体错误分离和细胞分裂错误，LGN缺陷导致Chudley-McCullough 综合征，以及多种微核表型。
观测值〜77 kDa。在某些细胞裂解物中，在~30 kDa、~60 kDa和 ~70 kDa处可能观察到未表征的条带。
Immunogen
GST标记的重组蛋白，对应于小鼠LGN。
Physical form
含 0.05％ 叠氮化钠的兔多克隆血清。
未纯化
Preparation Note
自收到之日起在-20°C可稳定保存1年。
使用建议：收货后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。分装到微量离心管中，并储存于-20°C。避免反复冻融循环，以免损坏IgG和影响产品性能。
使用建议：收货后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。分装到微量离心管中，并储存于-20°C。避免反复冻融循环，以免损坏IgG和影响产品性能。
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存储类别
10 - Combustible liquids
wgk
WGK 1
Carlos P Descovich et al.
eLife, 12 (2023-04-06)
Oriented cell divisions balance self-renewal and differentiation in stratified epithelia such as the skin epidermis. During peak epidermal stratification, the distribution of division angles among basal keratinocyte progenitors is bimodal, with planar and perpendicular divisions driving symmetric and asymmetric daughter
Kanako Chishiki et al.
Genes to cells : devoted to molecular & cellular mechanisms, 22(3), 293-309 (2017-02-12)
Correct cyst morphogenesis of epithelial cells requires apical-basal polarization, which is partly regulated by mitotic spindle orientation, a process dependent on the heterotrimeric G protein subunit Gαi and its binding protein LGN. Here, we show that in three-dimensional culture of
Ouranio Anastasiou et al.
Science signaling, 13(620) (2020-02-27)
Correct selection of the cell division axis is important for cell differentiation, tissue and organ morphogenesis, and homeostasis. Both integrins, which mediate interactions with extracellular matrix (ECM) components such as fibronectin, and cadherins, which mediate interactions between cells, are implicated
Par3-mInsc and G?i3 cooperate to promote oriented epidermal cell divisions through LGN.
Williams, SE; Ratliff, LA; Postiglione, MP; Knoblich, JA; Fuchs, E
Nature Cell Biology null
Kendall J Lough et al.
eLife, 8 (2019-12-14)
During organogenesis, precise control of spindle orientation balances proliferation and differentiation. In the developing murine epidermis, planar and perpendicular divisions yield symmetric and asymmetric fate outcomes, respectively. Classically, division axis specification involves centrosome migration and spindle rotation, events occurring early
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