产品名称
抗I型胶原抗体, from rabbit, purified by affinity chromatography
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, rat
technique(s)
ELISA: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... COL1A1(1277)
Analysis Note
对照
大鼠皮肤组织
大鼠皮肤组织
通过免疫组化在大鼠皮肤组织中进行了评估。
免疫组化分析：该抗体的1：100稀释液在大鼠皮肤组织中检测到1型胶原。
免疫组化分析：该抗体的1：100稀释液在大鼠皮肤组织中检测到1型胶原。
Application
使用经验证可用于蛋白质印迹、IHC（P）、ELISA的抗I型胶原抗体检测I型胶原。
特异性ELISA分析： 代表性批次在ELISA中检测到小鼠和大鼠胶原，但未检测到人胶原。
蛋白质印迹分析：代表性批次的1：2,000稀释液在10µg大鼠皮肤组织裂解物上检测到1型胶原。
蛋白质印迹分析：代表性批次的1：2,000稀释液在10µg大鼠皮肤组织裂解物上检测到1型胶原。
研究子类别
粘附（CAMs）
粘附（CAMs）
研究类别
细胞结构
细胞结构
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
胶原在整个进化过程中是高度保守的，其特征在于不间断的“甘氨酸X Y”三联体重复序列，其是三螺旋结构的必需部分。I型胶原（95kDa）存在于骨骼，角膜，皮肤和肌腱中。编码基因的突变与成骨不全症，埃勒斯·当洛斯综合征和特发性骨质疏松症有关。该基因和血小板衍生的生长因子β基因所在的染色体17和22之间的相互易位与称为隆突性皮肤纤维肉瘤的特定类型的皮肤肿瘤有关，这是由于生长因子的表达不受调节所致。
计算值为130 kDa
Immunogen
大鼠尾胶原
Other Notes
替代品：AB755P
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
亲和纯化
在含 0.1 M Tris-甘氨酸（pH 7.4），150 mM NaCl 和 0.05％ 叠氮化钠的缓冲液中的纯化的兔多克隆抗体。
Preparation Note
自收到之日起，在 2-8°C 条件下可稳定保存1年
未找到合适的产品？
试试我们的产品选型工具.
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Yuqin Zhang et al.
Frontiers in pharmacology, 13, 937484-937484 (2022-10-04)
Ethnopharmacological relevance: Pien-Tze-Huang (PZH)-a traditional Chinese medicine (TCM) compound-has been employed to treat various liver inflammation and tumors for over 10 decades. Interestingly, most of the pharmacological effects had been validated and explored toward liver ailment along with pro-inflammatory conditions and
Fernanda Cristina de Mesquita et al.
Scientific reports, 7(1), 3255-3255 (2017-06-14)
Hepatic stellate cells (HSC) play a key role in the development of chronic liver disease (CLD). Liraglutide, well-established in type 2 diabetes, showed anti-inflammatory and anti-oxidant properties. We evaluated the effects of liraglutide on HSC phenotype and hepatic microvascular function
Shira N Johnston et al.
Frontiers in cell and developmental biology, 12, 1360376-1360376 (2024-03-21)
Hypoxia-inducible factors (HIFs) are essential to the homeostasis of hypoxic tissues. Although HIF-2α, is expressed in nucleus pulposus (NP) cells, consequences of elevated HIF-2 activity on disc health remains unknown. We expressed HIF-2α with proline to alanine substitutions (P405A; P531A)
Yitong Zhang et al.
Molecular medicine reports, 19(1), 115-124 (2018-11-16)
Numerous studies have revealed that microRNAs (miRNAs) are functional non‑coding RNAs that serve roles in a variety of biological processes. However, the expression patterns and regulatory networks, as well as the miRNAs involved in liver fibrosis remain to be elucidated.
Takashi Ohnishi et al.
Cell death & disease, 14(7), 447-447 (2023-07-20)
Pathological mineralization of intervertebral disc is debilitating and painful and linked to disc degeneration in a subset of human patients. An adenosine triphosphate efflux transporter, progressive ankylosis (ANK) is a regulator of extracellular inorganic pyrophosphate levels and plays an important
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持