Anti-Lnk/SH2B adapter protein 3 Antibody

Lnk is an SH2B3 multidomain adaptor protein that is primarily expressed in lymphocytes. It contains the characteristic pleckstrin homology (PH); src homology 2 (SH2); dimerization; and proline-rich domains. Lnk functions as a negative regulator of B cell proliferative processes via interaction with Jak2 and Mpl proteins, and inhibition of the PI3/Akt/STAT5 signaling pathway. Previous studies have implicated Lnk in celiac disease type 13.

Other homologies: Rat (78% sequence homology) and Mouse (72% sequence homology).

This antibody recognizes Lnk/SH2B adapter protein 3 at the C-terminus.

Epitope: C-terminus

KLH-conjugated linear peptide corresponding to the C-terminus of human Lnk/SH2B adapter protein 3.

Detect the Lnk/SH2B adapter protein 3 protein using this Anti-Lnk/SH2B adapter protein 3 validated for use in WB.

Research Category
Cell Structure

Research Sub Category
Adhesion (CAMs)

Evaluated by Western Blot in HepG2 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Lnk/SH2B adapter protein 3 on 10 µg of HepG2 cell lysate.

~80 kDa observed. The calculated molecular weight is 63 kDa, however Lnk/SH2B adapter protein 3 has been shown as a ~80 kDa band in western blots (Li, Y., et al. (2000). J Immunol. 164:5199-5206.)

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
HepG2 cell lysate

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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