所有图片(3)
别名:
inositol 1,4,5-triphosphate receptor, type 1, spinocerebellar ataxia 16, inositol 1,4,5-trisphosphate receptor type 1, Type 1 inositol 1,4,5-trisphosphate receptor, Type 1 InsP3 receptor, IP3 receptor, spinocerebellar ataxia 15, IP3 receptor isoform 1
UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41
推荐产品
生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
rat, human, pig
种属反应性（根据同源性预测）
mouse (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology), primate (based on 100% sequence homology), porcine (based on 100% sequence homology)
技术
immunohistochemistry: suitable (paraffin)
immunoprecipitation (IP): suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... ITPR1(3708)
一般描述
The inositol (1,4,5)-trisphosphate receptor (InsP3R) regulates calcium release from storage within cells and plays an important role in neuronal function. InsP3R has been linked to Huntington’s disease. InsP3R has also been linked to the association between cAMP and Ca2+ signaling in regions of the brain, including the neostriatum.
特异性
This antibody recognizes InsP3R at the cytoplasmic domain.
免疫原
KLH-conjugated linear peptide corresponding to the cytoplasmic domain of rat InsP3R.
应用
Immunohistochemistry Analysis: 1:1500 dilution from a previous lot detected InsP3R in purkinje cells at the junction of the granular and molecular layers of normal rat cerebellum tissue.
Immunoprecipitation Analysis: 10 µg of Anti-InsP3R, Type 1 immunoprecipitated InsP3R, Type 1 from rat brain microsomal prep RIPA lysate.
Immunoprecipitation Analysis: 10 µg of Anti-InsP3R, Type 1 immunoprecipitated InsP3R, Type 1 from rat brain microsomal prep RIPA lysate.
This Anti-InsP3R Antibody, Type 1 is validated for use in WB, IP, IH(P) for the detection of InsP3R.
质量
Evaluated by Western Blot in rat brain microsomal tissue lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected InsP3R on 10 µg of rat brain microsomal tissue lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected InsP3R on 10 µg of rat brain microsomal tissue lysate.
目标描述
~300 kDa observed. UniProtKB/Swiss-Prot P29994 (ITPR1_RAT) entry describes 8 isoforms produced by alternative splicing: Isoform 1 at 313.264 kDa, Isoform 2 at 311.498 kDa, Isoform 3 at 313.136 kDa, Isoform 4 at 311.370 kDa, Isoform 5 at 311.210 kDa, Isoform 6 at 309.444 kDa, Isoform 7 at 308.674 kDa, and Isoform 8 at 306.909 kDa
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Melanie Vanessa Halbach et al.
Cerebellum (London, England), 16(1), 68-81 (2016-02-13)
Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominantly inherited neurodegenerative disorder with preferential affection of Purkinje neurons, which are known as integrators of calcium currents. The expansion of a polyglutamine (polyQ) domain in the RNA-binding protein ataxin-2 (ATXN2) is
Cesar Cardenas et al.
Science signaling, 13(640) (2020-07-16)
Spontaneous Ca2+ signaling from the InsP3R intracellular Ca2+ release channel to mitochondria is essential for optimal oxidative phosphorylation (OXPHOS) and ATP production. In cells with defective OXPHOS, reductive carboxylation replaces oxidative metabolism to maintain amounts of reducing equivalents and metabolic
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