产品名称
抗-精氨酸酶-1抗体, from chicken
biological source
chicken
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
species reactivity
guinea pig, human, mouse, rat
technique(s)
immunohistochemistry: suitable
western blot: suitable
isotype
IgY
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ARG1(383)
mouse ... Arg1(11846)
rat ... Arg1(29221)
Analysis Note
通过蛋白质印迹在小鼠LN组织裂解物中进行了评估。
蛋白质印迹分析：2.0 µg/mL该抗体在10 µg小鼠LN组织裂解物中检测到精氨酸酶-1。
蛋白质印迹分析：2.0 µg/mL该抗体在10 µg小鼠LN组织裂解物中检测到精氨酸酶-1。
Application
免疫组化分析：代表性批次在支气管肺泡灌洗细胞中检出精氨酸酶-1（Zimmermann, N., et al. (2003).J. Clin. Invest. 111:1863–1874 (2003)）。
蛋白质印迹分析：代表性批次在RAW细胞裂解物中检出精氨酸酶-1（Morris, S., et al. (1998).Am J Physiol Endocrinol Metab 275:E740-E747, 1998）。
蛋白质印迹分析：代表性批次在RAW细胞裂解物中检出精氨酸酶-1（Morris, S., et al. (1998).Am J Physiol Endocrinol Metab 275:E740-E747, 1998）。
研究类别
信号传导
信号传导
该抗精氨酸酶-1抗体经过验证可用在蛋白质印迹和免疫组化中检测精氨酸酶-1。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
精氨酸酶-1是ARG1基因编码的蛋白，是催化L-精氨酸分解为鸟氨酸和尿素的酶。ARG1是尿素循环的关键参与者。精氨酸酶有两种不同的亚型，精氨酸酶I和精氨酸酶II。精氨酸酶I（也称为肝型精氨酸酶或1型精氨酸酶）是肝脏和其他组织（包括大脑）中高度表达的胞质酶。精氨酸酶II或肾型精氨酸酶在许多组织中也以低水平广泛表达，但主要定位于线粒体。有趣的是，精氨酸酶1具有神经保护特性。精氨酸酶I对于保护运动神经元免受细胞应激或营养因子去除后可诱导的一氧化氮依赖性凋亡至关重要。通过抑制一氧化氮的产生，精氨酸酶可防止过氧亚硝酸盐的形成及其随后的细胞毒性。此外，精氨酸酶1似乎在整个中枢神经系统中对于神经元和轴突的存活和再生起关键作用。在癌症中，精氨酸酶1已经是肝细胞的有用标志物，也是肝细胞癌的极佳标志物。
观察值〜38 kDa
Immunogen
对应于大鼠精氨酸酶-1的全长重组蛋白。
Other Notes
浓度：请参考特定批次的数据表。
Physical form
卵黄纯化IgY
形式：纯化
纯鸡的兔多克隆抗体，溶于含0.05％叠氮化钠的PBS缓冲液中
Preparation Note
自发运之日起，在 2-8°C 条件下可稳定保存1年
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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