Anti-WNT10A Antibody

Wingless-type MMTV integration site family 10a (WNT10A) plays crucial role in normal development such as regulation of cell fate, patterning during embryogenesis and neoplastic transformation. Elevated levels of WNT10A have been detected in several human tumors and cancer cell lines including colorectal cancer and chronic lymphocytic leukemia. This evidence suggests that uncontrolled Wnt signaling may contribute to the abnormal apoptosis that characterizes these malignancies. Defects in WNT10A have been shown to be related and possibly are the cause of ectodermal dysplasia anhidrotic (EDA), also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Other recent evidence had suggested that mutation in WNT10A is associated with odonto-onycho-dermal dysplasia (OODD), an autosomal recessive ectodermal dysplasia and Schopf-Schulz-Passarge syndrome (SSPS).

KLH-conjugated linear peptide corresponding to human WNT10A.

Anti-WNT10A Antibody is a highly specific rabbit polyclonal antibody, that targets Wnt & has been tested in western blotting, IHC (Paraffin) & Immunofluorescence.

Immunohistochemistry Analysis: 10 µg/mL from a representative lot detected WNT10A in human skeletal muscle tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected WNT10A in human skeletal muscle cells.

Research Category
Signaling

Research Sub Category
Developmental Signaling

Evaluated by Western Blotting in RAW264.7 cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected WNT10A in 15 µg of RAW264.7 cell lysate.

~46 kDa observed. Uncharacterized bands may appear in some lysate(s).

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
RAW264.7 cell lysate

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.