Anti-Dio3 Antibody

The enzyme DIO3 is a critical enzyme in thyroid hormone metabolism. It converts the thyroid hormone T4 into the inactive form RT3 and it also converts the thyroid hormone T3 into the inactive form T2. It is thought that DIO3 plays a role in preventing premature exposure of the developing fetus to adult levels of thyroid hormones. DIO3 also regulates the levels of fetal thyroid hormones during gestation, thus DIO3 is critical for proper development and metabolism of the fetus during embryological development. DIO3 is expressed in the placenta and in fetal tissues, and DIO3 is localized to the cell membrane and endosomal membranes. DIO3 is also often expressed in neoplastic tissues and in particular basal cell carcinomas.

BSA-conjugated linear peptide corresponding to the extracellular domain of human Dio3.

Epitope: Extracellular domain

Anti-Dio3 Antibody is an antibody against Dio3 Antibody for use in Immunohistochemistry, Immunofluorescence.

Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected Dio3 in human placenta.
Immunohistochemistry Analysis: A representative lot detected Dio3 in Hepatic tissue (Huang, S.A., et al. (2001). Journal of Clinical Endocrinology & Metabolism. 87(10):4457–4461).
Immunohistochemistry Analysis: A representative lot detected Dio3 in human uterus, placenta, umbilical cord, fetal epithelial, and endometrium (Huang, S.A., et al. (2003). Journal of Clinical Endocrinology & Metabolism. 88(3):1384-1388).

Research Category
Signaling

Research Sub Category
Signaling Neuroscience

Evaluated by Immunohistochemistry in human uterus tissue.

Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Dio3 in human uterus tissue.

34 kDa calculated

Affinity purified

Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Concentration: Please refer to lot specific datasheet.

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