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Merck
CN

ABS1004

抗磷酸NKCC1抗体（Thr212/Thr217）

serum, from rabbit

别名:

phospho-NKCC1 Thr212/Thr217, Solute carrier family 12 member 2, Basolateral Na-K-Cl symporter, Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

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产品名称

抗磷酸NKCC1抗体（Thr212/Thr217）, serum, from rabbit

biological source

rabbit

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

technique(s)

immunofluorescence: suitable
western blot: suitable

NCBI accession no.

NP_001037

UniProt accession no.

P55011

shipped in

dry ice

target post-translational modification

phosphorylation (pThr212/pThr217)

Quality Level

100

Gene Information

human ... SLC12A2(6558)

相关类别

Analysis Note

通过蛋白质印迹对GMB43细胞裂解液进行了评估。

蛋白质印迹分析： 该抗体的1：1,000的稀释液在10 µg GMB43细胞裂解物中检测到磷酸-NKCC1 Thr212/Thr217。

Application

抗磷酸NKCC1 Thr212/Thr217是用于蛋白质印迹，免疫荧光的针对磷酸NKCC1的抗体。
研究子类别
信号神经科学
研究类别
信号传导
蛋白质印迹分析: 代表性批次在GMB43和GBM5细胞裂解物中检测到磷酸NKCC1 Thr212/Thr217（Dr. Anders Persson, UCSF) (Grim, R.P., et al. (2012)JBC.1-31）。
免疫荧光分析: 代表性批次在GBM43人组织中检测到磷酸NKCC1 Thr212/Thr217（Dr. Anders Persson, UCSF) (Grim, R.P., et al. (2012)JBC.1-31）。

Biochem/physiol Actions

特定于磷酸化NKCC1的成熟形式。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

General description

Na-K-Cl共转运蛋白1（NKCC1）是由SLC12A2基因编码的膜蛋白，在细胞钠/钾/氯化物转运和体内平衡中起作用。它广泛分布于全身并发挥重要作用，特别是在分泌液体的腺体中。NKCC1的细胞内N末端结构域中Thr212/Thr217的磷酸化与NKCC1激活相关。
观察值〜250 kDa。NKCC1可能是NKCC1的成熟形式的二聚体，在不同的细胞中被不同的糖基化，从而导致某些裂解物中的条带未表征。

Immunogen

对应于人磷酸-NKCC1 Thr212/Thr217的线性肽。

Other Notes

浓度：请参考特定批次的数据表。

Physical form

含 0.05％ 叠氮化钠的兔多克隆血清。
未纯化

Preparation Note

自收到之日起在-20°C可稳定保存1年。
使用建议：收到后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。分装到微量离心管中，并储存于 -20°C。避免反复冻融循环，以免损坏 IgG 和影响产品性能。

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存储类别

10 - Combustible liquids

wgk

WGK 1

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