ABN899
抗-寡糖-2 抗体
from rabbit, purified by affinity chromatography
别名:
Oligodendrocyte transcription factor 2, bHLHe19, Olg-2, Oligo2, RACK17, RK17
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ICC, IHC, IP, WB
Citations:
5
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, rat, human
technique(s)
immunocytochemistry: suitable, immunohistochemistry: suitable (paraffin), immunoprecipitation (IP): suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... OLIG2(10215)
General description
少突胶质细胞转录因子2（UniProt Q9EQW6；也称为bHLHe19，Olg-2，Oligo2，RACK17，RK17）由鼠物种中的Olig2（也称为Bhlhb1）基因（基因ID 50913）编码。Olig2是在脊髓心室区域表达的碱性螺旋-环-螺旋（bHLH）转录因子，在胚胎发生过程中介导运动神经元和少突胶质细胞的顺序生成。Olig2在早期时间点还充当pMN祖细胞中的抗神经源性因子，以维持循环祖细胞池。Olig2的抗神经源性也在肿瘤发生中起作用，特别是在脑肿瘤和白血病中。由于其在胶质母细胞瘤和其他弥漫性神经胶质瘤中的表达，Olig2是这些脑肿瘤的有用诊断标志物。
观察值〜37 kDa。计算值为32.40 kDa。
Immunogen
KLH偶联线性肽，对应于小鼠Olig-2的N末端区域中的序列。
Application
免疫沉淀分析：10 µg代表性批次免疫沉淀500 µg小鼠脑组织裂解物中的Olig-2。
免疫组化分析：代表性批次的1：500稀释液在大鼠后脑组织切片中检测到Olig-2。
免疫细胞化学分析：代表性批次的1：500稀释液在PC12细胞中检测到Olig-2。
免疫组化分析：代表性批次的1：500稀释液在大鼠后脑组织切片中检测到Olig-2。
免疫细胞化学分析：代表性批次的1：500稀释液在PC12细胞中检测到Olig-2。
抗Olig-2抗体是针对Olig-2的抗体，用于蛋白质印迹，免疫沉淀，免疫细胞化学，免疫组化（石蜡）。
Physical form
PBS和0.1 %叠氮化钠中的纯化的兔多克隆抗体。
Analysis Note
通过蛋白质印迹在小鼠脑组织裂解液中进行了评估。
蛋白质印迹分析：1.0 µg/mL的该抗体可在10 µg小鼠脑组织裂解物中检测到Olig-2。
蛋白质印迹分析：1.0 µg/mL的该抗体可在10 µg小鼠脑组织裂解物中检测到Olig-2。
Other Notes
替代品：AB15328
浓度：请参考特定批次的数据表。
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wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
存储类别
12 - Non Combustible Liquids
Shiji Deng et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 10(5), e2202976-e2202976 (2022-12-20)
White matter injury (WMI), which reflects myelin loss, contributes to cognitive decline or dementia caused by cerebral vascular diseases. However, because pharmacological agents specifically for WMI are lacking, novel therapeutic strategies need to be explored. It is recently found that
Kelsie Mozzoni LaBarbera et al.
Journal of neuroscience methods, 358, 109180-109180 (2021-04-10)
Mature primary neuronal cultures are an important model of the nervous system, but limited scalability has been a major challenge in their use for drug discovery of neurodegenerative diseases. This work describes a method for improving scalability through the use
Colleen S Limegrover et al.
Journal of neuroscience research, 99(4), 1161-1176 (2021-01-23)
α-Synuclein oligomers are thought to have a pivotal role in sporadic and familial Parkinson's disease (PD) and related α-synucleinopathies, causing dysregulation of protein trafficking, autophagy/lysosomal function, and protein clearance, as well as synaptic function impairment underlying motor and cognitive symptoms
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| ABN899 | 04055977329575 |