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Merck
CN
所有图片(2)

主要文件

ABN60

Sigma-Aldrich

抗色氨酸羟化酶2抗体

from rabbit, purified by affinity chromatography

别名:

tryptophan hydroxylase 2, Tryptophan 5-monooxygenase 2, Neuronal tryptophan hydroxylase, tryptophan 5-hydroxylase 2

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About This Item

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

rabbit

质量水平

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

纯化方式

affinity chromatography

种属反应性

human, rat

种属反应性(根据同源性预测)

mouse (immunogen homology)

技术

immunohistochemistry: suitable (paraffin)
western blot: suitable

NCBI登记号

UniProt登记号

运输

wet ice

靶向翻译后修饰

unmodified

基因信息

human ... TPH2(121278)

一般描述

色氨酸羟化酶2(TPH2)优先在大脑中表达,被认为在5-羟色胺合成中起重要作用。实际上,最近的研究表明TPH2的高水平与自杀的风险有关。TPH2的错误折叠可能是帕金森氏’病中5-羟色胺神经元功能丧失的原因。TPH2中特定突变的检测和筛选已被认为是预测患者对潜在抗抑郁疗法的敏感性甚至诊断行为障碍可能性的一种方法。

免疫原

对应于人色氨酸羟化酶2的KLH偶联线性肽。

应用

免疫组化分析: 先前批次的1:400稀释液在大鼠大脑皮层组织中检测到色氨酸羟化酶2。
抗色氨酸羟化酶2抗体可检测色氨酸羟化酶2的水平&已发表&经验证可用于WB,IH(P)。
研究子类别
信号神经科学
研究类别
神经科学

质量

通过蛋白质印迹对大鼠脑组织裂解物进行了评估。
蛋白质印迹分析:0.2 µg/mL该抗体在10 µg大鼠脑组织裂解物中检测到色氨酸羟化酶2。

目标描述

观察值〜56 kDa

外形

亲和纯化
在含 0.1 M Tris-甘氨酸(pH 7.4),150 mM NaCl 和 0.05% 叠氮化钠的缓冲液中的纯化的兔多克隆抗体。

分析说明

对照
大鼠脑组织裂解物

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Yong Han et al.
Nature communications, 12(1), 3525-3525 (2021-06-12)
Contrasting to the established role of the hypothalamic agouti-related protein (AgRP) neurons in feeding regulation, the neural circuit and signaling mechanisms by which they control energy expenditure remains unclear. Here, we report that energy expenditure is regulated by a subgroup
Yong Han et al.
Science advances, 7(22) (2021-05-28)
The neural circuitry mechanism that underlies dopaminergic (DA) control of innate feeding behavior is largely uncharacterized. Here, we identified a subpopulation of DA neurons situated in the caudal ventral tegmental area (cVTA) directly innervating DRD1-expressing neurons within the lateral parabrachial
Lauren J Donovan et al.
eLife, 8 (2019-07-30)
Formation of long-range axons occurs over multiple stages of morphological maturation. However, the intrinsic transcriptional mechanisms that temporally control different stages of axon projection development are unknown. Here, we addressed this question by studying the formation of mouse serotonin (5-HT)
Weixin Zhong et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(37), 8863-8875 (2017-08-20)
The ability to predict reward promotes animal survival. Both dopamine neurons in the ventral tegmental area and serotonin neurons in the dorsal raphe nucleus (DRN) participate in reward processing. Although the learning effects on dopamine neurons have been extensively characterized
Mary Gazea et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(22), 4840-4849 (2021-04-24)
The lateral hypothalamus (LH), together with multiple neuromodulatory systems of the brain, such as the dorsal raphe nucleus (DR), is implicated in arousal, yet interactions between these systems are just beginning to be explored. Using a combination of viral tracing

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