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生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
mouse
种属反应性(根据同源性预测)
human (based on 100% sequence homology)
技术
western blot: suitable
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... DISC1(27185)
一般描述
Disrupted in schizophrenia 1 protein (DISC1) is involved in the regulation of multiple aspects of embryonic and adult neurogenesis. DISC1 may play a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. DISC1 is shown to inhibit the activation of AKT-mTOR signaling upon interaction with CCDC88A. DISC1 is required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Additionally, DISC1 is suggested to regulate the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. DISC1 has been shown to participates in the Wnt-mediated neural progenitor proliferation as a positive regulator and may have a role, together with PCNT, in the microtubule network formation.
DICS1 is highly expressed in the dentate gyrus of the hippocampus. It is also expressed in the temporal and parahippocampal cortices and cells of the white matter. Expression rises within the dentate gyrus and temporal cortex from the neonatal period to infancy, declines markedly in adolescence, and declines further with aging. Uniprot describes 8 isoforms ranging between ~37 kDa and ~94 kDa.
DICS1 is highly expressed in the dentate gyrus of the hippocampus. It is also expressed in the temporal and parahippocampal cortices and cells of the white matter. Expression rises within the dentate gyrus and temporal cortex from the neonatal period to infancy, declines markedly in adolescence, and declines further with aging. Uniprot describes 8 isoforms ranging between ~37 kDa and ~94 kDa.
特异性
This antibody recognizes the N-terminus of DISC1.
免疫原
Epitope: N-terminus
KLH-conjugated linear peptide corresponding to the N-terminus of human DISC1.
应用
Anti-DISC1 Antibody is a highly specific rabbit polyclonal antibody, that targets Disc1 & has been tested in western blotting.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Neuroscience
Developmental Neuroscience
质量
Evaluated by Western Blotting in NIH/3T3 cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected DISC1 in 15 µg of NIH/3T3 cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected DISC1 in 15 µg of NIH/3T3 cell lysate.
目标描述
~95 kDa observed. Uncharacterized bands may appear in some lysates. Uniprot describes 8 isoforms ranging between ~37 kDa and ~94 kDa
外形
Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
分析说明
Control
NIH/3T3 cell lysate
NIH/3T3 cell lysate
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
BMC neuroscience, 25(1), 12-12 (2024-03-05)
Mutations in the gene DISC1 are associated with increased risk for schizophrenia, bipolar disorder and major depression. The study of mutated DISC1 represents a well-known and comprehensively characterized approach to understand neuropsychiatric disease mechanisms. However, previous studies have mainly used
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