ABN418
抗-TRPM4抗体
from rabbit, purified by affinity chromatography
别名:
Transient receptor potential cation channel subfamily M member 4, hTRPM4, Calcium-activated non-selective cation, channel 1, Long transient receptor potential channel 4, LTrpC-4, LTrpC4, Melastatin-4
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所有图片(2)
About This Item
UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41
推荐产品
生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
human, rat
种属反应性（根据同源性预测）
mouse (based on 100% sequence homology), monkey (based on 100% sequence homology), chimpanzee (based on 100% sequence homology)
技术
immunohistochemistry: suitable
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... TRPM4(54795)
一般描述
TRPM4，也称为钙激活非选择性阳离子通道1、长瞬时受体电位通道4、Melastatin-4或LTrpC4，由基因TRPM4/LTRPC4，是一种针对Na+、K+、Cs+和Li+离子的钙激活非选择性离子通道。TRPM4在心肌细胞、皮质和背根神经元、内分泌细胞、肾上皮细胞甚至毛细胞的膜去极化中起着核心作用。此外，TRPM4通过上调β连环蛋白信号通路参与T细胞活化、IL-2产生、血管收缩、胰岛素分泌甚至各种细胞类型的细胞增殖。TRPM4位于细胞膜，高尔基体和内质网。TRPM4广泛表达。TRPM4的缺陷可能与进行性家族性心传导阻滞疾病有关，虽然是不可预测的综合征但可能致命。
免疫原
对应于N末端附近的人TRPM4的BCP偶联的线性肽。
应用
免疫组化分析：代表性批次的1：50稀释液在人小脑和人前列腺组织中检测到TRPM4。
抗TRPM4抗体可检测TRPM4的水平&已发布 & 经验证可用于TRPM4。
质量
通过蛋白质印迹对人小脑组织裂解物进行了评估。
蛋白质印迹分析：0.5 µg/mL该抗体在10 µg人小脑组织裂解物中检测到TRPM4。
蛋白质印迹分析：0.5 µg/mL该抗体在10 µg人小脑组织裂解物中检测到TRPM4。
目标描述
观察值〜150 kDa。Uniprot描述了通过在~130 kDa和~147 kDa处选择性剪接产生的2种亚型
其他说明
浓度：请参考批次特异性浓缩物的分析证书。
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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