ABN418
抗-TRPM4抗体
from rabbit, purified by affinity chromatography
别名:
Transient receptor potential cation channel subfamily M member 4, hTRPM4, Calcium-activated non-selective cation, channel 1, Long transient receptor potential channel 4, LTrpC-4, LTrpC4, Melastatin-4
产品名称
抗-TRPM4抗体, from rabbit, purified by affinity chromatography
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, rat
species reactivity (predicted by homology)
mouse (based on 100% sequence homology), monkey (based on 100% sequence homology), chimpanzee (based on 100% sequence homology)
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TRPM4(54795)
Analysis Note
通过蛋白质印迹对人小脑组织裂解物进行了评估。
蛋白质印迹分析：0.5 µg/mL该抗体在10 µg人小脑组织裂解物中检测到TRPM4。
蛋白质印迹分析：0.5 µg/mL该抗体在10 µg人小脑组织裂解物中检测到TRPM4。
Application
免疫组化分析：代表性批次的1：50稀释液在人小脑和人前列腺组织中检测到TRPM4。
抗TRPM4抗体可检测TRPM4的水平&已发布 & 经验证可用于TRPM4。
General description
TRPM4，也称为钙激活非选择性阳离子通道1、长瞬时受体电位通道4、Melastatin-4或LTrpC4，由基因TRPM4/LTRPC4，是一种针对Na+、K+、Cs+和Li+离子的钙激活非选择性离子通道。TRPM4在心肌细胞、皮质和背根神经元、内分泌细胞、肾上皮细胞甚至毛细胞的膜去极化中起着核心作用。此外，TRPM4通过上调β连环蛋白信号通路参与T细胞活化、IL-2产生、血管收缩、胰岛素分泌甚至各种细胞类型的细胞增殖。TRPM4位于细胞膜，高尔基体和内质网。TRPM4广泛表达。TRPM4的缺陷可能与进行性家族性心传导阻滞疾病有关，虽然是不可预测的综合征但可能致命。
观察值〜150 kDa。Uniprot描述了通过在~130 kDa和~147 kDa处选择性剪接产生的2种亚型
Immunogen
对应于N末端附近的人TRPM4的BCP偶联的线性肽。
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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