产品名称
Anti-ORMDL3 Antibody, from rabbit, purified by affinity chromatography
biological source
rabbit
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
species reactivity (predicted by homology)
horse (based on 100% sequence homology), monkey (based on 100% sequence homology), canine (based on 100% sequence homology)
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ORMDL3(94103)
Analysis Note
Evaluated by Western Blotting in human brain tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected ORMDL3 in 10 µg of human brain tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected ORMDL3 in 10 µg of human brain tissue lysate.
Application
Anti-ORMDL3 Antibody detects level of ORMDL3 & has been published & validated for use in ORMDL3.
Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected ORMDL3 in human thalamus and human lung tissue.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Signaling
Developmental Signaling
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
The protein named ORM1-like protein 3 (ORMDL3), and encoded by the human gene ORMDL3 belongs to a novel gene family of endoplasmic reticulum membrane proteins that are highly conserved and ubiquitously expressed in adult and fetal tissues. ORMDL3 is a negative regulator of sphingolipid biosynthesis and may indirectly regulate endoplasmic reticulum-mediated calcium signaling. Also in lung tissue, ORMDL3 is an inducible epithelial protein that regulates metalloproteases, chemokines, oligoadenylate synthetases and activates activating transcription factor 6 (ATF6), a critical protein in the unfolded protein response immune response pathway which plays an important role in our response to infections and pathology. The discovery of the link between ORMDL3 and the unfolded protein response pathway may be part of the mechanism of how ORMDL3 is involved in the asthmatic response and regulation. Defects and polymorphims in ORMDL3 gene are linked with Asthma and with asthmatic response profiles.
~19 kDa observed
Immunogen
Blue carrier protein-conjugated linear peptide corresponding to human near C-Terminal of ORMDL3.
Epitope: Near C-Terminal
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Briana N James et al.
The Journal of allergy and clinical immunology, 147(5), 1936-1948 (2020-11-02)
Nothing is known about the mechanisms by which increased ceramide levels in the lung contribute to allergic responses and asthma severity. We sought to investigate the functional role of ceramide in mouse models of allergic airway disease that recapitulate the
Tian Xie et al.
Nature communications, 14(1), 3475-3475 (2023-06-13)
The ORM/ORMDL family proteins function as regulatory subunits of the serine palmitoyltransferase (SPT) complex, which is the initiating and rate-limiting enzyme in sphingolipid biosynthesis. This complex is tightly regulated by cellular sphingolipid levels, but the sphingolipid sensing mechanism is unknown.
Siddharth Srivastava et al.
Brain : a journal of neurology, 146(4), 1420-1435 (2023-02-01)
Sphingolipids are a diverse family of lipids with critical structural and signalling functions in the mammalian nervous system, where they are abundant in myelin membranes. Serine palmitoyltransferase, the enzyme that catalyses the rate-limiting reaction of sphingolipid synthesis, is composed of
Shaheer Ahmad et al.
Antioxidants (Basel, Switzerland), 13(8) (2024-08-31)
Exposure to heavy metals (HMs) is often associated with inflammation and cell death, exacerbating respiratory diseases including asthma. Most inhaled particulate HM exposures result in the deposition of HM-bound fine particulate matter, PM2.5, in pulmonary cell populations. While localized high
Linda Sasset et al.
EMBO reports, 24(1), e54689-e54689 (2022-11-22)
Disruption of sphingolipid homeostasis and signaling has been implicated in diabetes, cancer, cardiometabolic, and neurodegenerative disorders. Yet, mechanisms governing cellular sensing and regulation of sphingolipid homeostasis remain largely unknown. In yeast, serine palmitoyltransferase, catalyzing the first and rate-limiting step of
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